Healthcare resource utilization and costs associated with acute graft-versus-host disease following allogeneic hematopoietic cell transplantation

Jingbo Yu, Lincy Lal, Amy Anderson, Mary DuCharme, Shreekant Parasuraman, Daniel Weisdorf

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


PURPOSE: The contribution of acute graft-versus-host disease (GVHD) to healthcare resource utilization (HCRU) and costs following allogeneic hematopoietic cell transplantation (HCT) has not been extensively investigated. The objective of this study was to estimate both inpatient and outpatient HCRU and costs associated with acute GVHD during the 100-day and 1-year periods after allogeneic HCT in the USA.

METHODS: A retrospective analysis of administrative claims from the Optum® Research Database of patients aged ≥ 12 years who received HCT between 2010 and 2016 was conducted. Costs and HCRU among patients with acute GVHD and no GVHD were compared during the 100-day (acute GVHD, n = 723; no GVHD, n = 385) and 360-day (acute GVHD, n = 445; no GVHD, n = 227) periods after HCT.

RESULTS: Patients with acute GVHD had significantly more (P < 0.001) mean office visits (47 vs 32), hospital outpatient visits (71 vs 35), and inpatient stays (2.8 vs 1.1) than patients with no GVHD during 360 days post-HCT; similar findings were observed over the 100-day period. Mean total all-cause costs were significantly higher (P < 0.001) for patients with acute GVHD versus no GVHD during both post-HCT periods (100-day, $316,458 vs $215,229; 360-day, $466,720 vs $263,568). Additional factors associated with increased 360-day costs included young age (12-17 years; P < 0.001) and peripheral blood as graft source (P = 0.03).

CONCLUSION: Acute GVHD was associated with significant HCRU and costs in the first 100 days of transplant, increasing over the first year post-HCT. Inpatient care was the primary driver, but outpatient care and related costs were also increased.

Original languageEnglish (US)
Pages (from-to)5491-5499
Number of pages9
JournalSupportive Care in Cancer
Issue number11
StatePublished - Nov 1 2020

Bibliographical note

Funding Information:
The study was funded by Incyte Corporation. Acknowledgments

Funding Information:
Writing assistance was provided by Jane Kovalevich, PhD, at Complete Healthcare Communications, LLC (North Wales, PA), a CHC Group company, and was funded by Incyte Corporation.

Publisher Copyright:
© 2020, Springer-Verlag GmbH Germany, part of Springer Nature.


  • Acute graft-versus-host disease
  • Allogeneic hematopoietic cell transplantation
  • Inpatient healthcare resource utilization
  • Total costs
  • Hematopoietic Stem Cell Transplantation/adverse effects
  • Graft vs Host Disease/economics
  • United States
  • Humans
  • Middle Aged
  • Male
  • Health Resources/statistics & numerical data
  • Transplantation, Homologous
  • Young Adult
  • Adolescent
  • Adult
  • Female
  • Aged
  • Retrospective Studies
  • Child
  • Patient Acceptance of Health Care/statistics & numerical data

PubMed: MeSH publication types

  • Journal Article


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