TY - JOUR
T1 - Health-related Quality of Life in Pediatric Patients with Chronic Hepatitis B Living in the United States and Canada
AU - Schwarzenberg, Sarah Jane
AU - Ling, Simon C.
AU - Cloonan, Yona Keich
AU - Lin, Hsing Hua S.
AU - Evon, Donna M.
AU - Murray, Karen F.
AU - Rodriguez-Baez, Norberto
AU - Rosenthal, Philip
AU - Teckman, Jeffrey
AU - Schwarz, Kathleen B.
N1 - Publisher Copyright:
Copyright © ESPGHAL and NASPGHAN. All rights reserved.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Objectives: The aim of the study was to determine whether selected sociodemographic and hepatitis B virus (HBV)-specific clinical factors are associated with health-related quality of life (HRQoL) among pediatric patients chronically infected with HBV. Methods: Children with chronic HBV enrolled in the Hepatitis B Research Network completed the Child Health Questionnaire at study entry. Caregivers of children 5 to <10 years completed the parent-reported form (CHQ-Parent Report Form); youth 10 to <18 years completed the child-reported CHQ-Child Report Form. We examined univariable associations of the Child Health Questionnaire scores with selected independent variables: sex, adoption status, maternal education, alanine aminotransferase (U/L), aspartate aminotransferase-to-platelet ratio index, and HBV-specific symptom count. Results: A total of 244 participants (83 young children 5-<10 years, 161 youth 10-<18 years) were included, all HBV treatment-naïve. Among young children, increased alanine aminotransferase level was negatively associated with CHQ-Parent Report Form psychosocial summary t score (r=-0.28, P=0.01). No other subscale comparisons for young children were statistically significant. Among youth, adoption was associated with better physical functioning and general health (P<0.01). Higher maternal education was associated with better role/functioning-physical and -emotional scores (P<0.05). Maternal education and adoption status were linked with adoption associated with higher maternal education. Increased symptom count in youth was associated with worse HRQoL in subscales measuring bodily pain, behavior, mental health, and self-esteem (P<0.01). Conclusions: Although overall HRQoL is preserved in children with chronic HBV, some sociodemographic and HBV-related clinical factors were associated with impaired HRQoL in our pediatric patients at baseline. Measurement of HRQoL can focus resources on education and psychosocial support in children and families most in need.
AB - Objectives: The aim of the study was to determine whether selected sociodemographic and hepatitis B virus (HBV)-specific clinical factors are associated with health-related quality of life (HRQoL) among pediatric patients chronically infected with HBV. Methods: Children with chronic HBV enrolled in the Hepatitis B Research Network completed the Child Health Questionnaire at study entry. Caregivers of children 5 to <10 years completed the parent-reported form (CHQ-Parent Report Form); youth 10 to <18 years completed the child-reported CHQ-Child Report Form. We examined univariable associations of the Child Health Questionnaire scores with selected independent variables: sex, adoption status, maternal education, alanine aminotransferase (U/L), aspartate aminotransferase-to-platelet ratio index, and HBV-specific symptom count. Results: A total of 244 participants (83 young children 5-<10 years, 161 youth 10-<18 years) were included, all HBV treatment-naïve. Among young children, increased alanine aminotransferase level was negatively associated with CHQ-Parent Report Form psychosocial summary t score (r=-0.28, P=0.01). No other subscale comparisons for young children were statistically significant. Among youth, adoption was associated with better physical functioning and general health (P<0.01). Higher maternal education was associated with better role/functioning-physical and -emotional scores (P<0.05). Maternal education and adoption status were linked with adoption associated with higher maternal education. Increased symptom count in youth was associated with worse HRQoL in subscales measuring bodily pain, behavior, mental health, and self-esteem (P<0.01). Conclusions: Although overall HRQoL is preserved in children with chronic HBV, some sociodemographic and HBV-related clinical factors were associated with impaired HRQoL in our pediatric patients at baseline. Measurement of HRQoL can focus resources on education and psychosocial support in children and families most in need.
KW - Child Health Questionnaire
KW - adoption
KW - children
KW - chronic medical condition
KW - hepatitis B
KW - quality of life
KW - refugee
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U2 - 10.1097/MPG.0000000000001525
DO - 10.1097/MPG.0000000000001525
M3 - Article
C2 - 28169971
AN - SCOPUS:85011805777
SN - 0277-2116
VL - 64
SP - 760
EP - 769
JO - Journal of pediatric gastroenterology and nutrition
JF - Journal of pediatric gastroenterology and nutrition
IS - 5
ER -
