Health-related Quality of Life in Pediatric Patients with Chronic Hepatitis B Living in the United States and Canada

Sarah Jane Schwarzenberg, Simon C. Ling, Yona Keich Cloonan, Hsing Hua S. Lin, Donna M. Evon, Karen F. Murray, Norberto Rodriguez-Baez, Philip Rosenthal, Jeffrey Teckman, Kathleen B. Schwarz

Research output: Contribution to journalArticle

Abstract

Objectives: The aim of the study was to determine whether selected sociodemographic and hepatitis B virus (HBV)-specific clinical factors are associated with health-related quality of life (HRQoL) among pediatric patients chronically infected with HBV. Methods: Children with chronic HBV enrolled in the Hepatitis B Research Network completed the Child Health Questionnaire at study entry. Caregivers of children 5 to <10 years completed the parent-reported form (CHQ-Parent Report Form); youth 10 to <18 years completed the child-reported CHQ-Child Report Form. We examined univariable associations of the Child Health Questionnaire scores with selected independent variables: sex, adoption status, maternal education, alanine aminotransferase (U/L), aspartate aminotransferase-to-platelet ratio index, and HBV-specific symptom count. Results: A total of 244 participants (83 young children 5-<10 years, 161 youth 10-<18 years) were included, all HBV treatment-naïve. Among young children, increased alanine aminotransferase level was negatively associated with CHQ-Parent Report Form psychosocial summary t score (r=-0.28, P=0.01). No other subscale comparisons for young children were statistically significant. Among youth, adoption was associated with better physical functioning and general health (P<0.01). Higher maternal education was associated with better role/functioning-physical and -emotional scores (P<0.05). Maternal education and adoption status were linked with adoption associated with higher maternal education. Increased symptom count in youth was associated with worse HRQoL in subscales measuring bodily pain, behavior, mental health, and self-esteem (P<0.01). Conclusions: Although overall HRQoL is preserved in children with chronic HBV, some sociodemographic and HBV-related clinical factors were associated with impaired HRQoL in our pediatric patients at baseline. Measurement of HRQoL can focus resources on education and psychosocial support in children and families most in need.

Original languageEnglish (US)
Pages (from-to)760-769
Number of pages10
JournalJournal of pediatric gastroenterology and nutrition
Volume64
Issue number5
DOIs
StatePublished - May 1 2017

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Chronic Hepatitis B
Canada
Hepatitis B virus
Quality of Life
Pediatrics
Education
Mothers
Alanine Transaminase
Aspartate Aminotransferases
Hepatitis B
Self Concept
Aspartic Acid
Caregivers
Mental Health
Blood Platelets
Pain
Health

Keywords

  • Child Health Questionnaire
  • adoption
  • children
  • chronic medical condition
  • hepatitis B
  • quality of life
  • refugee

Cite this

Health-related Quality of Life in Pediatric Patients with Chronic Hepatitis B Living in the United States and Canada. / Schwarzenberg, Sarah Jane; Ling, Simon C.; Cloonan, Yona Keich; Lin, Hsing Hua S.; Evon, Donna M.; Murray, Karen F.; Rodriguez-Baez, Norberto; Rosenthal, Philip; Teckman, Jeffrey; Schwarz, Kathleen B.

In: Journal of pediatric gastroenterology and nutrition, Vol. 64, No. 5, 01.05.2017, p. 760-769.

Research output: Contribution to journalArticle

Schwarzenberg, SJ, Ling, SC, Cloonan, YK, Lin, HHS, Evon, DM, Murray, KF, Rodriguez-Baez, N, Rosenthal, P, Teckman, J & Schwarz, KB 2017, 'Health-related Quality of Life in Pediatric Patients with Chronic Hepatitis B Living in the United States and Canada', Journal of pediatric gastroenterology and nutrition, vol. 64, no. 5, pp. 760-769. https://doi.org/10.1097/MPG.0000000000001525
Schwarzenberg, Sarah Jane ; Ling, Simon C. ; Cloonan, Yona Keich ; Lin, Hsing Hua S. ; Evon, Donna M. ; Murray, Karen F. ; Rodriguez-Baez, Norberto ; Rosenthal, Philip ; Teckman, Jeffrey ; Schwarz, Kathleen B. / Health-related Quality of Life in Pediatric Patients with Chronic Hepatitis B Living in the United States and Canada. In: Journal of pediatric gastroenterology and nutrition. 2017 ; Vol. 64, No. 5. pp. 760-769.
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AU - Evon, Donna M.

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