Health-related quality of life in patients with cutaneous T-cell lymphoma?

Heather M. Holahan, Ronda S. Farah, Sara Fitz, Sarah L. Mott, Nkanyezi N. Ferguson, Julie McKillip, Brian Link, Vincent Liu

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Background: Little is currently known about health-related quality of life (HRQoL) of patients with cutaneous T-cell lymphoma (CTCL), a condition characterized by chronic, pruritic, visible lesions, features which may be uniquely influential. Objective: The aim of this study was to establish baseline HRQoL data for patients with CTCL and identify its influencing factors. Methods: Prospective, nonblinded survey design utilizing questionnaires including panels of QoL indices obtained from 105 patients with mycosis fungoides, Sezary syndrome, and CD30+ lymphoproliferative disorder. Chart review correlated QoL with year of disease onset/diagnosis, type/stage of disease, current/past therapies, and medical/psychiatric diagnoses. Results: Psychiatric condition was significantly associated with symptoms (P < 0.01), emotions (P < 0.01), and functioning (P < 0.03) subscales along with overall composite measure (P < 0.01). High-grade systemic therapy (OR = 5.28) showed greater increase in odds of a lower health state than low grade (OR = 1.54). The number of medical comorbidities was significantly related to itching (P < 0.01). Increased age was a protective factor with respect to the emotions (P < 0.01), functioning (P < 0.01), and overall composite (P < 0.01) but not predictive of symptoms. Lower income was associated with higher bother on the symptoms subscale. Conclusions: HRQoL in CTCL appears related to a number of factors, including presence of a psychiatric condition, use of systemic (particularly high grade) therapy, number of medical comorbidities, and income.

Original languageEnglish (US)
Pages (from-to)1314-1319
Number of pages6
JournalInternational Journal of Dermatology
Issue number11
StatePublished - Nov 2018

Bibliographical note

Publisher Copyright:
© 2018 The International Society of Dermatology


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