Health-related quality of life in patients with cutaneous T-cell lymphoma?

Heather M. Holahan, Ronda S Farah, Sara Fitz, Sarah L. Mott, Nkanyezi N. Ferguson, Julie McKillip, Brian Link, Vincent Liu

Research output: Contribution to journalArticle

Abstract

Background: Little is currently known about health-related quality of life (HRQoL) of patients with cutaneous T-cell lymphoma (CTCL), a condition characterized by chronic, pruritic, visible lesions, features which may be uniquely influential. Objective: The aim of this study was to establish baseline HRQoL data for patients with CTCL and identify its influencing factors. Methods: Prospective, nonblinded survey design utilizing questionnaires including panels of QoL indices obtained from 105 patients with mycosis fungoides, Sezary syndrome, and CD30+ lymphoproliferative disorder. Chart review correlated QoL with year of disease onset/diagnosis, type/stage of disease, current/past therapies, and medical/psychiatric diagnoses. Results: Psychiatric condition was significantly associated with symptoms (P < 0.01), emotions (P < 0.01), and functioning (P < 0.03) subscales along with overall composite measure (P < 0.01). High-grade systemic therapy (OR = 5.28) showed greater increase in odds of a lower health state than low grade (OR = 1.54). The number of medical comorbidities was significantly related to itching (P < 0.01). Increased age was a protective factor with respect to the emotions (P < 0.01), functioning (P < 0.01), and overall composite (P < 0.01) but not predictive of symptoms. Lower income was associated with higher bother on the symptoms subscale. Conclusions: HRQoL in CTCL appears related to a number of factors, including presence of a psychiatric condition, use of systemic (particularly high grade) therapy, number of medical comorbidities, and income.

Original languageEnglish (US)
Pages (from-to)1314-1319
Number of pages6
JournalInternational Journal of Dermatology
Volume57
Issue number11
DOIs
StatePublished - Nov 1 2018

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Cutaneous T-Cell Lymphoma
Quality of Life
Psychiatry
Comorbidity
Emotions
Sezary Syndrome
Mycosis Fungoides
Lymphoproliferative Disorders
Pruritus
Mental Disorders
Therapeutics
Health
Surveys and Questionnaires

PubMed: MeSH publication types

  • Journal Article

Cite this

Holahan, H. M., Farah, R. S., Fitz, S., Mott, S. L., Ferguson, N. N., McKillip, J., ... Liu, V. (2018). Health-related quality of life in patients with cutaneous T-cell lymphoma? International Journal of Dermatology, 57(11), 1314-1319. https://doi.org/10.1111/ijd.14132

Health-related quality of life in patients with cutaneous T-cell lymphoma? / Holahan, Heather M.; Farah, Ronda S; Fitz, Sara; Mott, Sarah L.; Ferguson, Nkanyezi N.; McKillip, Julie; Link, Brian; Liu, Vincent.

In: International Journal of Dermatology, Vol. 57, No. 11, 01.11.2018, p. 1314-1319.

Research output: Contribution to journalArticle

Holahan, HM, Farah, RS, Fitz, S, Mott, SL, Ferguson, NN, McKillip, J, Link, B & Liu, V 2018, 'Health-related quality of life in patients with cutaneous T-cell lymphoma?', International Journal of Dermatology, vol. 57, no. 11, pp. 1314-1319. https://doi.org/10.1111/ijd.14132
Holahan, Heather M. ; Farah, Ronda S ; Fitz, Sara ; Mott, Sarah L. ; Ferguson, Nkanyezi N. ; McKillip, Julie ; Link, Brian ; Liu, Vincent. / Health-related quality of life in patients with cutaneous T-cell lymphoma?. In: International Journal of Dermatology. 2018 ; Vol. 57, No. 11. pp. 1314-1319.
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AU - Link, Brian

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