Health-related quality of life (HR-QOL) and chronic health conditions in survivors of childhood acute myeloid leukemia (AML) with down syndrome (DS): A report from the children's oncology group

Kris Ann P Schultz, Lu Chen, Alicia Kunin-Batson, Zhengjia Chen, William G. Woods, Alan Gamis, Toana Kawashima, Kevin C. Oeffinger, H. Stacy Nicholson, Joseph P. Neglia

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Survival rates for children with Down syndrome (DS) and acute myeloid leukemia (AML) are high; however, little is known regarding the health-related quality of life (HR-QOL) of these survivors. Individuals who survived Z5 years following diagnosis of childhood AML were invited to complete parent or patient-report surveys measuring HR-QOL and chronic health conditions. In total, 26 individuals with DS had a median age at diagnosis of 1.8 years (range, 0.77 to 10.9 y) and median age at interview of 15 years (range, 8.3 to 27.6 y). Participants with DS and AML were compared with AML survivors without DS whose caregiver completed a HR-QOL survey (CHQ-PF50). In total, 77% of survivors with DS reported Z1 chronic health condition compared with 50% of AML survivors without DS (P=0.07). Mean physical and psychosocial QOL scores for children with DS and AML were statistically lower than the population mean, though not discrepant from AML survivors without DS. Although the overall prevalence of chronic health conditions in survivors with DS is higher than in survivors without DS, prior studies of children with DS have reported similarly high rates of chronic health conditions, suggesting that AML therapy may not substantially increase this risk.

Original languageEnglish (US)
Pages (from-to)20-25
Number of pages6
JournalJournal of pediatric hematology/oncology
Volume39
Issue number1
DOIs
StatePublished - 2017

Bibliographical note

Funding Information:
Supported by Children's Cancer Research Fund, Children's Oncology Group, and the National Cancer Institute (U24CA55727, 5U10 CA07306, and 1R01CA78960).

Publisher Copyright:
Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

Keywords

  • Chemotherapy
  • Down syndrome
  • Leukemia
  • Quality of life

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