Recent evidence suggests that dysregulated translation and its control significantly contribute to the etiology and pathogenesis of the head and neck cancers, specifically to that of squamous cell carcinoma (HNSCC). eIF4E is one of the most studied components of the translation machinery implicated in the development and progression of HNSCC. It appears that dysregulation of eIF4E levels and activity, namely by the PI3K/AKT/mTOR pathway, plays an important role in the etiology and pathogenesis of HNSCC and correlates with clinical outcomes. In this chapter, we will discuss the role of eIF4E and some other translation factors as they relate to the biology and treatment of HNSCC.
|Original language||English (US)|
|Title of host publication||Translation and Its Regulation in Cancer Biology and Medicine|
|Number of pages||14|
|ISBN (Print)||9401790779, 9789401790772|
|State||Published - Mar 1 2014|
Bibliographical notePublisher Copyright:
© 2014 Springer Science+Business Media Dordrecht. All rights reserved.
- Head and neck cancer
- Head and neck squamous cell carcinoma (HNSCC)
- Targeted therapy
- Therapeutic resistance
- Tumor margin
- mTOR pathway