Head and neck cancers

Cherie Ann O. Nathan, Oleksandr Ekshyyan, Arunkumar Anandharaj

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent evidence suggests that dysregulated translation and its control significantly contribute to the etiology and pathogenesis of the head and neck cancers, specifically to that of squamous cell carcinoma (HNSCC). eIF4E is one of the most studied components of the translation machinery implicated in the development and progression of HNSCC. It appears that dysregulation of eIF4E levels and activity, namely by the PI3K/AKT/mTOR pathway, plays an important role in the etiology and pathogenesis of HNSCC and correlates with clinical outcomes. In this chapter, we will discuss the role of eIF4E and some other translation factors as they relate to the biology and treatment of HNSCC.

Original languageEnglish (US)
Title of host publicationTranslation and Its Regulation in Cancer Biology and Medicine
PublisherSpringer Netherlands
Pages499-512
Number of pages14
ISBN (Electronic)9789401790789
ISBN (Print)9401790779, 9789401790772
DOIs
StatePublished - Mar 1 2014

Keywords

  • Biomarker
  • Head and neck cancer
  • Head and neck squamous cell carcinoma (HNSCC)
  • MNK
  • Targeted therapy
  • Therapeutic resistance
  • Translation
  • Tumor margin
  • eIF4E
  • mTOR pathway

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