TY - JOUR
T1 - Head and neck cancer treatment and physical plasma
AU - Metelmann, Hans Robert
AU - Nedrelow, David S.
AU - Seebauer, Christian
AU - Schuster, Matthias
AU - von Woedtke, Thomas
AU - Weltmann, Klaus Dieter
AU - Kindler, Stefan
AU - Metelmann, Philine Henriette
AU - Finkelstein, Steven E.
AU - Von Hoff, Daniel D.
AU - Podmelle, Fred
N1 - Publisher Copyright:
© 2015 Elsevier GmbH.
PY - 2015/6/1
Y1 - 2015/6/1
N2 - This study is a retrospective review of representing clinical follow-up of 12 patients afflicted with advanced squamous cell carcinoma of the head and neck. Herein, we have used novel physical cold atmospheric pressure plasma (CAP) to decontaminate infected cancer ulcerations and evaluated anti-cancer effects. With use of CAP in this cohort, the data suggests: (1) decreased request for pain medication and (2) reduction of typical fetid odor related to (3) reduction of microbial load. In some cases there is (4) superficial partial remission of tumor and even (5) wound healing of infected ulcerations has been observed following CAP exposure. As a result, CAP treatment appears of benefit for select head and neck cancer patients and future work to optimize CAP in the therapeutic armamentarium advances.
AB - This study is a retrospective review of representing clinical follow-up of 12 patients afflicted with advanced squamous cell carcinoma of the head and neck. Herein, we have used novel physical cold atmospheric pressure plasma (CAP) to decontaminate infected cancer ulcerations and evaluated anti-cancer effects. With use of CAP in this cohort, the data suggests: (1) decreased request for pain medication and (2) reduction of typical fetid odor related to (3) reduction of microbial load. In some cases there is (4) superficial partial remission of tumor and even (5) wound healing of infected ulcerations has been observed following CAP exposure. As a result, CAP treatment appears of benefit for select head and neck cancer patients and future work to optimize CAP in the therapeutic armamentarium advances.
KW - CAP
KW - Cold atmospheric pressure plasma
KW - Decontamination infected cancer ulceration
KW - Medical plasma
KW - Reduction microbial load
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=84931562938&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931562938&partnerID=8YFLogxK
U2 - 10.1016/j.cpme.2015.02.001
DO - 10.1016/j.cpme.2015.02.001
M3 - Article
AN - SCOPUS:84931562938
SN - 2212-8166
VL - 3
SP - 17
EP - 23
JO - Clinical Plasma Medicine
JF - Clinical Plasma Medicine
IS - 1
ER -
