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HDAC6 inhibition restores ciliary expression and decreases tumor growth
Sergio A. Gradilone
, Brynn N. Radtke
, Pamela S. Bogert
, Bing Q. Huang
, Gabriella B. Gajdos
, Nicholas F. LaRusso
Research output
:
Contribution to journal
›
Article
›
peer-review
187
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Scopus citations
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Keyphrases
Tumor Growth
100%
Histone Deacetylase 6 (HDAC6)
100%
Ciliary
100%
Primary Cilia
85%
Cholangiocarcinoma
85%
Deciliation
57%
Tumor Cells
42%
Cholangiocytes
42%
Cilia
42%
Anchorage-independent Growth
42%
Tubastatin A
42%
Short Hairpin RNA (shRNA)
28%
Cell Proliferation
14%
Malignant Transformation
14%
Overexpression
14%
Potential Therapeutics
14%
Epithelial Cells
14%
Pharmacological Inhibitors
14%
Multisensory
14%
Hedgehog Signaling
14%
Mitogen-activated Protein Kinase
14%
Tumor Biology
14%
Stable Transfection
14%
Proliferation Rate
14%
Cell Lining
14%
Cholangiocarcinoma Cells
14%
Cholangiocarcinoma Cell Line
14%
Multiple Processes
14%
Biliary Tree
14%
IFT88
14%
Bile Components
14%
Medicine and Dentistry
Tumor Progression
100%
Cholangiocarcinoma
100%
Histone Deacetylase 6
100%
Primary Cilium
85%
Tumor Cell
42%
Cilium
42%
Anchorage Independent Growth
42%
Cholangiocyte
42%
Short Hairpin RNA
28%
Epithelial Cell
14%
Cell Proliferation
14%
Malignant Transformation
14%
Sonic Hedgehog Protein
14%
Bile
14%
Tumor Biology
14%
Cholangiocarcinoma Cell Line
14%
Cell Anchorage
14%
Stable Transfection
14%
Mitogen-Activated Protein Kinase
14%
Hedgehog Signaling
14%