HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis - involvement of ERK pathway

Jing Wang; Ying H. Shen; Budi Utama; Jian Wang; Scott A. LeMaire; Joseph S. Coselli; Greg M. Vercellotti; Xing Li Wang

doi:10.1016/j.febslet.2006.04.041

HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis - involvement of ERK pathway

Jing Wang
, Ying H. Shen
, Budi Utama
, Jian Wang
, Scott A. LeMaire
, Joseph S. Coselli
, Greg M. Vercellotti
, Xing Li Wang

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H₂O₂-induced cell death - a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H₂O₂ (0-2 mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease.

Original language	English (US)
Pages (from-to)	2779-2787
Number of pages	9
Journal	FEBS Letters
Volume	580
Issue number	11
DOIs	https://doi.org/10.1016/j.febslet.2006.04.041
State	Published - May 15 2006

Bibliographical note

Funding Information:
This project is supported by Grant NIH R01-HL071608 to X.L.W. Dr. Xing Li Wang is an AHA Established Investigator.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis
Cytomegalovirus
Endothelium
Hydrogen peroxide

Publisher link

10.1016/j.febslet.2006.04.041

Find It

Find It at U of M Libraries

Cite this

@article{03a1d1ff9bcc434ea416d640f171506f,

title = "HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis - involvement of ERK pathway",

abstract = "Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H2O2-induced cell death - a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H2O2 (0-2 mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease.",

keywords = "Apoptosis, Cytomegalovirus, Endothelium, Hydrogen peroxide",

author = "Jing Wang and Shen, \{Ying H.\} and Budi Utama and Jian Wang and LeMaire, \{Scott A.\} and Coselli, \{Joseph S.\} and Vercellotti, \{Greg M.\} and Wang, \{Xing Li\}",

note = "Funding Information: This project is supported by Grant NIH R01-HL071608 to X.L.W. Dr. Xing Li Wang is an AHA Established Investigator.",

year = "2006",

month = may,

day = "15",

doi = "10.1016/j.febslet.2006.04.041",

language = "English (US)",

volume = "580",

pages = "2779--2787",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "John Wiley and Sons Inc.",

number = "11",

}

TY - JOUR

T1 - HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis - involvement of ERK pathway

AU - Wang, Jing

AU - Shen, Ying H.

AU - Utama, Budi

AU - Wang, Jian

AU - LeMaire, Scott A.

AU - Coselli, Joseph S.

AU - Vercellotti, Greg M.

AU - Wang, Xing Li

N1 - Funding Information: This project is supported by Grant NIH R01-HL071608 to X.L.W. Dr. Xing Li Wang is an AHA Established Investigator.

PY - 2006/5/15

Y1 - 2006/5/15

N2 - Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H2O2-induced cell death - a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H2O2 (0-2 mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease.

AB - Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H2O2-induced cell death - a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H2O2 (0-2 mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease.

KW - Apoptosis

KW - Cytomegalovirus

KW - Endothelium

KW - Hydrogen peroxide

UR - https://www.scopus.com/pages/publications/33646477958

UR - https://www.scopus.com/pages/publications/33646477958#tab=citedBy

U2 - 10.1016/j.febslet.2006.04.041

DO - 10.1016/j.febslet.2006.04.041

M3 - Article

C2 - 16650413

AN - SCOPUS:33646477958

SN - 0014-5793

VL - 580

SP - 2779

EP - 2787

JO - FEBS Letters

JF - FEBS Letters

IS - 11

ER -

HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis - involvement of ERK pathway

Abstract

Bibliographical note

UN SDGs

Keywords

Publisher link

Find It

Other files and links

Fingerprint

Cite this