HCMV infection attenuates hydrogen peroxide induced endothelial apoptosis - involvement of ERK pathway

Jing Wang, Ying H. Shen, Budi Utama, Jian Wang, Scott A. LeMaire, Joseph S. Coselli, Greg M. Vercellotti, Xing Li Wang

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Human cytomegalovirus (HCMV) exerts anti-apoptotic effect during early stage of infection, which provides HCMV time for propagation. We investigated pathways mediating the resistance to H2O2-induced cell death - a self-defense mechanism to remove infected cells. We found that human aortic endothelial cells (HAECs) infected with VHL/E strain of HCMV during first 3 days were resistant to H2O2 (0-2 mM) induced apoptosis. This anti-apoptotic effect may be mediated by the upregulation of Bcl-2, an anti-apoptotic protein through the activation pro-survival pathway extracellular signal regulated kinase (ERK). Through this mechanism, HCMV is able to propagate and causes endothelial dysfunction, hence vascular disease.

Original languageEnglish (US)
Pages (from-to)2779-2787
Number of pages9
JournalFEBS Letters
Volume580
Issue number11
DOIs
StatePublished - May 15 2006

Bibliographical note

Funding Information:
This project is supported by Grant NIH R01-HL071608 to X.L.W. Dr. Xing Li Wang is an AHA Established Investigator.

Keywords

  • Apoptosis
  • Cytomegalovirus
  • Endothelium
  • Hydrogen peroxide

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