Harvesting Potential Dissolution Advantages of Soluble Cocrystals by Depressing Precipitation Using the Common Coformer Effect

Hiroyuki Yamashita, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

A highly soluble cocrystal of a poorly soluble drug has the potential to improve the dissolution rate and bioavailability. Reaping the potential dissolution advantage of soluble cocrystals is challenged by the precipitation of the parent drug during dissolution. Using the carbamazepine-nicotinamide cocrystal, we show that the use of excess coformer can be an effective strategy for eliminating precipitation during dissolution by taking advantage of the "common coformer effect". When excess coformer is present, the solubility of the cocrystal is depressed, which leads to a lower degree of supersaturation. At an appropriate level, precipitation can be prevented and improved dissolution is realized.

Original languageEnglish (US)
Pages (from-to)6719-6721
Number of pages3
JournalCrystal Growth and Design
Volume16
Issue number12
DOIs
StatePublished - Dec 7 2016

Fingerprint Dive into the research topics of 'Harvesting Potential Dissolution Advantages of Soluble Cocrystals by Depressing Precipitation Using the Common Coformer Effect'. Together they form a unique fingerprint.

Cite this