Recent findings revealed endogenous cardiomyocyte replenishment upon myocardial injuries in mice and continuous cardiomyocyte renewal throughout the human life. These important findings not only confirmed the cardiac regenerative potentials of the adult myocardium, but also hinted a novel strategy for cardiac repair by renewing cardiomyocytes. In this review, we discuss target cardiogenic stem cell populations and approaches to unleash their cardiac regeneration potentials.
Bibliographical noteFunding Information:
This work was supported by the National Science Council (grant numbers NSC 97-IR-082, NSC 96-2314-B-006-021 and NSC 97-3111-B-006-005), the National Health Research Institutes (grant number NHRI EX97-22SI) and the NCKU Integrated Landmark Project (grant number 97-I006).