Haploidentical bone marrow transplantation for osteopetrosis

Paul J. Orchard; Joseph D. Dickerman; Catharina H.E. Mathews; Sharon Frierdich; Richard Hong; Michael E. Trigg; Nasrollah T. Shahidi; Jonathan L. Finlay; Paul M. Sondel

doi:10.1097/00043426-198724000-00011

Haploidentical bone marrow transplantation for osteopetrosis

Paul J. Orchard, Joseph D. Dickerman, Catharina H.E. Mathews, Sharon Frierdich, Richard Hong, Michael E. Trigg, Nasrollah T. Shahidi, Jonathan L. Finlay, Paul M. Sondel

Pediatrics - Blood/Marrow Transplant

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

HLA-matched bone marrow transplantation is an effective form of treatment for some patients with malignant osteopetrosis, a defect of osteoclast function. Following transplant, normal osteoclasts differentiate from donor-derived marrow stem cells and can function normally in some of these patients. For patients without an HLA-matched marrow donor, pharmacologic treatments have not yet proved effective. This article demonstrates that normal osteoclast function can be obtained following the transplantation of HLA-nonidentical marrow that has been purged of T lymphocytes in vitro.

Original language	English (US)
Pages (from-to)	335-340
Number of pages	6
Journal	Journal of pediatric hematology/oncology
Volume	9
Issue number	4
DOIs	https://doi.org/10.1097/00043426-198724000-00011
State	Published - 1987

Keywords

Bone marrow transplantation
Osteopetrosis
T cell depletion

Access

10.1097/00043426-198724000-00011

Fingerprint Dive into the research topics of 'Haploidentical bone marrow transplantation for osteopetrosis'. Together they form a unique fingerprint.

Cite this

Haploidentical bone marrow transplantation for osteopetrosis. / Orchard, Paul J.; Dickerman, Joseph D.; Mathews, Catharina H.E.; Frierdich, Sharon; Hong, Richard; Trigg, Michael E.; Shahidi, Nasrollah T.; Finlay, Jonathan L.; Sondel, Paul M.

In: Journal of pediatric hematology/oncology, Vol. 9, No. 4, 1987, p. 335-340.

Research output: Contribution to journal › Article › peer-review

@article{bcfec802ecd244f3a4ca231d862ec22b,

title = "Haploidentical bone marrow transplantation for osteopetrosis",

abstract = "HLA-matched bone marrow transplantation is an effective form of treatment for some patients with malignant osteopetrosis, a defect of osteoclast function. Following transplant, normal osteoclasts differentiate from donor-derived marrow stem cells and can function normally in some of these patients. For patients without an HLA-matched marrow donor, pharmacologic treatments have not yet proved effective. This article demonstrates that normal osteoclast function can be obtained following the transplantation of HLA-nonidentical marrow that has been purged of T lymphocytes in vitro.",

keywords = "Bone marrow transplantation, Osteopetrosis, T cell depletion",

author = "Orchard, {Paul J.} and Dickerman, {Joseph D.} and Mathews, {Catharina H.E.} and Sharon Frierdich and Richard Hong and Trigg, {Michael E.} and Shahidi, {Nasrollah T.} and Finlay, {Jonathan L.} and Sondel, {Paul M.}",

year = "1987",

doi = "10.1097/00043426-198724000-00011",

language = "English (US)",

volume = "9",

pages = "335--340",

journal = "Journal of Pediatric Hematology/Oncology",

issn = "1077-4114",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Haploidentical bone marrow transplantation for osteopetrosis

AU - Orchard, Paul J.

AU - Dickerman, Joseph D.

AU - Mathews, Catharina H.E.

AU - Frierdich, Sharon

AU - Hong, Richard

AU - Trigg, Michael E.

AU - Shahidi, Nasrollah T.

AU - Finlay, Jonathan L.

AU - Sondel, Paul M.

PY - 1987

Y1 - 1987

N2 - HLA-matched bone marrow transplantation is an effective form of treatment for some patients with malignant osteopetrosis, a defect of osteoclast function. Following transplant, normal osteoclasts differentiate from donor-derived marrow stem cells and can function normally in some of these patients. For patients without an HLA-matched marrow donor, pharmacologic treatments have not yet proved effective. This article demonstrates that normal osteoclast function can be obtained following the transplantation of HLA-nonidentical marrow that has been purged of T lymphocytes in vitro.

AB - HLA-matched bone marrow transplantation is an effective form of treatment for some patients with malignant osteopetrosis, a defect of osteoclast function. Following transplant, normal osteoclasts differentiate from donor-derived marrow stem cells and can function normally in some of these patients. For patients without an HLA-matched marrow donor, pharmacologic treatments have not yet proved effective. This article demonstrates that normal osteoclast function can be obtained following the transplantation of HLA-nonidentical marrow that has been purged of T lymphocytes in vitro.

KW - Bone marrow transplantation

KW - Osteopetrosis

KW - T cell depletion

UR - http://www.scopus.com/inward/record.url?scp=0023485771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023485771&partnerID=8YFLogxK

U2 - 10.1097/00043426-198724000-00011

DO - 10.1097/00043426-198724000-00011

M3 - Article

C2 - 3326419

AN - SCOPUS:0023485771

VL - 9

SP - 335

EP - 340

JO - Journal of Pediatric Hematology/Oncology

JF - Journal of Pediatric Hematology/Oncology

SN - 1077-4114

IS - 4

ER -