Haploidentical bone marrow transplantation for osteopetrosis

Paul J. Orchard, Joseph D. Dickerman, Catharina H.E. Mathews, Sharon Frierdich, Richard Hong, Michael E. Trigg, Nasrollah T. Shahidi, Jonathan L. Finlay, Paul M. Sondel

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

HLA-matched bone marrow transplantation is an effective form of treatment for some patients with malignant osteopetrosis, a defect of osteoclast function. Following transplant, normal osteoclasts differentiate from donor-derived marrow stem cells and can function normally in some of these patients. For patients without an HLA-matched marrow donor, pharmacologic treatments have not yet proved effective. This article demonstrates that normal osteoclast function can be obtained following the transplantation of HLA-nonidentical marrow that has been purged of T lymphocytes in vitro.

Original languageEnglish (US)
Pages (from-to)335-340
Number of pages6
JournalJournal of pediatric hematology/oncology
Volume9
Issue number4
DOIs
StatePublished - 1987

Keywords

  • Bone marrow transplantation
  • Osteopetrosis
  • T cell depletion

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