Abstract
HLA-matched bone marrow transplantation is an effective form of treatment for some patients with malignant osteopetrosis, a defect of osteoclast function. Following transplant, normal osteoclasts differentiate from donor-derived marrow stem cells and can function normally in some of these patients. For patients without an HLA-matched marrow donor, pharmacologic treatments have not yet proved effective. This article demonstrates that normal osteoclast function can be obtained following the transplantation of HLA-nonidentical marrow that has been purged of T lymphocytes in vitro.
Original language | English (US) |
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Pages (from-to) | 335-340 |
Number of pages | 6 |
Journal | Journal of pediatric hematology/oncology |
Volume | 9 |
Issue number | 4 |
DOIs | |
State | Published - 1987 |
Keywords
- Bone marrow transplantation
- Osteopetrosis
- T cell depletion