Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning

Chen S. Tsai; Rong W. Mao; Yun Zhu; Eric Chien; James Maduzia; Shirley C. Tsai; Matthew Brenner; Sari Mahon; David Mukai; Jangwoen Lee; David Yoon; Tanya Berney; Gerry Boss; Steve Patterson

doi:10.1109/ULTSYM.2012.0409

Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning

Chen S. Tsai, Rong W. Mao, Yun Zhu, Eric Chien, James Maduzia, Shirley C. Tsai, Matthew Brenner, Sari Mahon, David Mukai, Jangwoen Lee, David Yoon, Tanya Berney, Gerry Boss, Steve Patterson

Center for Drug Design

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

Detoxification of massive cyanide (CN) poisoning by inhalation of antidotes is recognized to be superior to intra venous (IV) or intra muscular (IM) treatment with regard to ease of administration, self-administration, and rapidity of onset. However, there are currently no effective, portable, high-throughput inhalers that can be produced in large quantities and distributed for such purpose. A hand-held inhaler has been realized using silicon-based ultrasonic nozzle to produce high-throughput of monodisperse cobinamide antidote solution for detoxification of CN poisoning in a rabbit model.

Original language	English (US)
Title of host publication	2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages	1632-1634
Number of pages	3
DOIs	https://doi.org/10.1109/ULTSYM.2012.0409
State	Published - 2012
Event	2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany Duration: Oct 7 2012 → Oct 10 2012

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Other

Other	2012 IEEE International Ultrasonics Symposium, IUS 2012
Country	Germany
City	Dresden
Period	10/7/12 → 10/10/12

Bibliographical note

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

Fourier-horn ultrasonic nozzles
cobinamide antidote
cyanide poisoning and detoxification
monodisperse aerosol inhaler

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10.1109/ULTSYM.2012.0409

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Tsai, C. S., Mao, R. W., Zhu, Y., Chien, E., Maduzia, J., Tsai, S. C., Brenner, M., Mahon, S., Mukai, D., Lee, J., Yoon, D., Berney, T., Boss, G., & Patterson, S. (2012). Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning. In 2012 IEEE International Ultrasonics Symposium, IUS 2012 (pp. 1632-1634). [6562116] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2012.0409

Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning. / Tsai, Chen S.; Mao, Rong W.; Zhu, Yun; Chien, Eric; Maduzia, James; Tsai, Shirley C.; Brenner, Matthew; Mahon, Sari; Mukai, David; Lee, Jangwoen; Yoon, David; Berney, Tanya; Boss, Gerry; Patterson, Steve.

2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 1632-1634 6562116 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Tsai, CS, Mao, RW, Zhu, Y, Chien, E, Maduzia, J, Tsai, SC, Brenner, M, Mahon, S, Mukai, D, Lee, J, Yoon, D, Berney, T, Boss, G & Patterson, S 2012, Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning. in 2012 IEEE International Ultrasonics Symposium, IUS 2012., 6562116, IEEE International Ultrasonics Symposium, IUS, pp. 1632-1634, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 10/7/12. https://doi.org/10.1109/ULTSYM.2012.0409

Tsai, Chen S. ; Mao, Rong W. ; Zhu, Yun ; Chien, Eric ; Maduzia, James ; Tsai, Shirley C. ; Brenner, Matthew ; Mahon, Sari ; Mukai, David ; Lee, Jangwoen ; Yoon, David ; Berney, Tanya ; Boss, Gerry ; Patterson, Steve. / Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning. 2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. pp. 1632-1634 (IEEE International Ultrasonics Symposium, IUS).

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abstract = "Detoxification of massive cyanide (CN) poisoning by inhalation of antidotes is recognized to be superior to intra venous (IV) or intra muscular (IM) treatment with regard to ease of administration, self-administration, and rapidity of onset. However, there are currently no effective, portable, high-throughput inhalers that can be produced in large quantities and distributed for such purpose. A hand-held inhaler has been realized using silicon-based ultrasonic nozzle to produce high-throughput of monodisperse cobinamide antidote solution for detoxification of CN poisoning in a rabbit model.",

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AU - Maduzia, James

AU - Tsai, Shirley C.

AU - Brenner, Matthew

AU - Mahon, Sari

AU - Mukai, David

AU - Lee, Jangwoen

AU - Yoon, David

AU - Berney, Tanya

AU - Boss, Gerry

AU - Patterson, Steve

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AB - Detoxification of massive cyanide (CN) poisoning by inhalation of antidotes is recognized to be superior to intra venous (IV) or intra muscular (IM) treatment with regard to ease of administration, self-administration, and rapidity of onset. However, there are currently no effective, portable, high-throughput inhalers that can be produced in large quantities and distributed for such purpose. A hand-held inhaler has been realized using silicon-based ultrasonic nozzle to produce high-throughput of monodisperse cobinamide antidote solution for detoxification of CN poisoning in a rabbit model.

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Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning

Abstract

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Bibliographical note

Keywords

Access

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