Hand-held high-throughput ultrasonic monodisperse aerosol inhalers for detoxification of massive cyanide poisoning

Chen S. Tsai, Rong W. Mao, Yun Zhu, Eric Chien, James Maduzia, Shirley C. Tsai, Matthew Brenner, Sari Mahon, David Mukai, Jangwoen Lee, David Yoon, Tanya Berney, Gerry Boss, Steve Patterson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Detoxification of massive cyanide (CN) poisoning by inhalation of antidotes is recognized to be superior to intra venous (IV) or intra muscular (IM) treatment with regard to ease of administration, self-administration, and rapidity of onset. However, there are currently no effective, portable, high-throughput inhalers that can be produced in large quantities and distributed for such purpose. A hand-held inhaler has been realized using silicon-based ultrasonic nozzle to produce high-throughput of monodisperse cobinamide antidote solution for detoxification of CN poisoning in a rabbit model.

Original languageEnglish (US)
Title of host publication2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages1632-1634
Number of pages3
DOIs
StatePublished - 2012
Event2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany
Duration: Oct 7 2012Oct 10 2012

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2012 IEEE International Ultrasonics Symposium, IUS 2012
CountryGermany
CityDresden
Period10/7/1210/10/12

Bibliographical note

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

  • Fourier-horn ultrasonic nozzles
  • cobinamide antidote
  • cyanide poisoning and detoxification
  • monodisperse aerosol inhaler

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