Haematogones in the peripheral blood of adults: A four-colour flow cytometry study of 102 patients

Steven H. Kroft; Sheryl L. Asplund; Robert W. McKenna; Nitin J. Karandikar

doi:10.1111/j.1365-2141.2004.05011.x

Haematogones in the peripheral blood of adults: A four-colour flow cytometry study of 102 patients

Steven H. Kroft, Sheryl L. Asplund, Robert W. McKenna, Nitin J. Karandikar

Research output: Contribution to journal › Article › peer-review

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Abstract

Haematogones have been extensively characterized in bone marrow, but not in the peripheral blood (PB). We studied 102 PB samples from adult patients with a sensitive flow cytometry method. Sixty-six of 102 samples (65%) contained detectable haematogones, ranging from 0.01% to 1.3% of white blood cells (median 0.06%, mean 0.13%). Of 66 cases with complete blood count data, 51 had absolute haematogone counts of 0.00037-0.105 × 10⁹/l (median 0.0054 × 10⁹/l, mean 0.012 × 10⁹/l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma.

Original language	English (US)
Pages (from-to)	209-212
Number of pages	4
Journal	British journal of haematology
Volume	126
Issue number	2
DOIs	https://doi.org/10.1111/j.1365-2141.2004.05011.x
State	Published - Jul 2004
Externally published	Yes

Keywords

B-cell precursors
CD10
Flow cytometry
Haematogones

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-2141.2004.05011.x

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abstract = "Haematogones have been extensively characterized in bone marrow, but not in the peripheral blood (PB). We studied 102 PB samples from adult patients with a sensitive flow cytometry method. Sixty-six of 102 samples (65%) contained detectable haematogones, ranging from 0.01% to 1.3% of white blood cells (median 0.06%, mean 0.13%). Of 66 cases with complete blood count data, 51 had absolute haematogone counts of 0.00037-0.105 × 109/l (median 0.0054 × 109/l, mean 0.012 × 109/l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma.",

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AU - Kroft, Steven H.

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AU - McKenna, Robert W.

AU - Karandikar, Nitin J.

PY - 2004/7

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N2 - Haematogones have been extensively characterized in bone marrow, but not in the peripheral blood (PB). We studied 102 PB samples from adult patients with a sensitive flow cytometry method. Sixty-six of 102 samples (65%) contained detectable haematogones, ranging from 0.01% to 1.3% of white blood cells (median 0.06%, mean 0.13%). Of 66 cases with complete blood count data, 51 had absolute haematogone counts of 0.00037-0.105 × 109/l (median 0.0054 × 109/l, mean 0.012 × 109/l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma.

AB - Haematogones have been extensively characterized in bone marrow, but not in the peripheral blood (PB). We studied 102 PB samples from adult patients with a sensitive flow cytometry method. Sixty-six of 102 samples (65%) contained detectable haematogones, ranging from 0.01% to 1.3% of white blood cells (median 0.06%, mean 0.13%). Of 66 cases with complete blood count data, 51 had absolute haematogone counts of 0.00037-0.105 × 109/l (median 0.0054 × 109/l, mean 0.012 × 109/l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma.

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Haematogones in the peripheral blood of adults: A four-colour flow cytometry study of 102 patients

Abstract

Keywords

UN SDGs

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