Gut microbiota composition and blood pressure: The CARDIA study

Shan Sun, Anju Lulla, Michael Sioda, Kathryn Winglee, Michael C. Wu, David R. Jacobs, James M. Shikany, Donald M. Lloyd-Jones, Lenore J. Launer, Anthony A. Fodor, Katie A. Meyer

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Animal models support a role for the gut microbiota in the development of hypertension. There has been a lack of epidemiological cohort studies to confirm these findings in human populations. We examined cross-sectional associations between measures of gut microbial diversity and taxonomic composition and blood pressure (BP) in 529 participants of the biracial (black and white) CARDIA study (Coronary Artery Risk Development in Young Adults). We sequenced V3-V4 regions of the 16S ribosomal RNA marker gene using DNA extracted from stool samples collected at CARDIA's Year 30 follow-up examination (2015-2016; aged 48-60 years). We quantified associations between BP (hypertension [defined as systolic BP ≥140 mm Hg or diastolic BP ≥90 mm Hg or antihypertension medication use] and systolic BP) and within and between-person diversity measures. We conducted genera-specific multivariable-adjusted regression analysis, accounting for multiple comparisons using the false discovery rate. Hypertension and systolic BP were inversely associated with measures of α-diversity, including richness and the Shannon Diversity Index, and were distinguished with respect to principal coordinates based on a similarity matrix of genera abundance. Several specific genera were significantly associated with hypertension and systolic BP, though results were attenuated with adjustment for body mass index. Our findings support associations between within-person and between-person gut microbial community diversity and taxonomic composition and BP in a diverse population-based cohort of middle-aged adults. Future study is needed to define functional pathways that underlie observed associations and identify specific microbial targets for intervention.

Original languageEnglish (US)
Pages (from-to)998-1006
Number of pages9
JournalHypertension
Volume73
Issue number5
DOIs
StatePublished - May 1 2019

Fingerprint

Blood Pressure
Hypertension
Gastrointestinal Microbiome
16S Ribosomal RNA
rRNA Genes
Population
Epidemiologic Studies
Young Adult
Coronary Vessels
Body Mass Index
Cohort Studies
Animal Models
Regression Analysis
DNA

Keywords

  • blood pressure
  • epidemiology
  • gastrointestinal microbiome
  • hypertension
  • population

PubMed: MeSH publication types

  • Comparative Study
  • Journal Article
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

Cite this

Sun, S., Lulla, A., Sioda, M., Winglee, K., Wu, M. C., Jacobs, D. R., ... Meyer, K. A. (2019). Gut microbiota composition and blood pressure: The CARDIA study. Hypertension, 73(5), 998-1006. https://doi.org/10.1161/HYPERTENSIONAHA.118.12109

Gut microbiota composition and blood pressure : The CARDIA study. / Sun, Shan; Lulla, Anju; Sioda, Michael; Winglee, Kathryn; Wu, Michael C.; Jacobs, David R.; Shikany, James M.; Lloyd-Jones, Donald M.; Launer, Lenore J.; Fodor, Anthony A.; Meyer, Katie A.

In: Hypertension, Vol. 73, No. 5, 01.05.2019, p. 998-1006.

Research output: Contribution to journalArticle

Sun, S, Lulla, A, Sioda, M, Winglee, K, Wu, MC, Jacobs, DR, Shikany, JM, Lloyd-Jones, DM, Launer, LJ, Fodor, AA & Meyer, KA 2019, 'Gut microbiota composition and blood pressure: The CARDIA study', Hypertension, vol. 73, no. 5, pp. 998-1006. https://doi.org/10.1161/HYPERTENSIONAHA.118.12109
Sun, Shan ; Lulla, Anju ; Sioda, Michael ; Winglee, Kathryn ; Wu, Michael C. ; Jacobs, David R. ; Shikany, James M. ; Lloyd-Jones, Donald M. ; Launer, Lenore J. ; Fodor, Anthony A. ; Meyer, Katie A. / Gut microbiota composition and blood pressure : The CARDIA study. In: Hypertension. 2019 ; Vol. 73, No. 5. pp. 998-1006.
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