Gut Homeostasis, Microbial Dysbiosis, and Opioids

Fuyuan Wang, Sabita Roy

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Gut homeostasis plays an important role in maintaining animal and human health. The disruption of gut homeostasis has been shown to be associated with multiple diseases. The mutually beneficial relationship between the gut microbiota and the host has been demonstrated to maintain homeostasis of the mucosal immunity and preserve the integrity of the gut epithelial barrier. Currently, rapid progress in the understanding of the host-microbial interaction has redefined toxicological pathology of opioids and their pharmacokinetics. However, it is unclear how opioids modulate the gut microbiome and metabolome. Our study, showing opioid modulation of gut homeostasis in mice, suggests that medical interventions to ameliorate the consequences of drug use/abuse will provide potential therapeutic and diagnostic strategies for opioid-modulated intestinal infections. The study of morphine's modulation of the gut microbiome and metabolome will shed light on the toxicological pathology of opioids and its role in the susceptibility to infectious diseases.

Original languageEnglish (US)
Pages (from-to)150-156
Number of pages7
JournalToxicologic Pathology
Volume45
Issue number1
DOIs
StatePublished - Jan 1 2017

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Keywords

  • dysbiosis
  • gut microbiota
  • homeostasis
  • opioid-related disorders

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