Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates

Emily P. Van Syoc; Andres Gomez; Emily R. Davenport; Seth R. Bordenstein

doi:10.1371/journal.pbio.3003390

Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates

Emily P. Van Syoc
, Andres Gomez
, Emily R. Davenport
, Seth R. Bordenstein

Animal Science

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Fungi in the gut microbiome, collectively known as the mycobiome, are a prevalent yet neglected component of the human holobiont. A major question in the study of gut microbial communities is whether fungi exhibit eco-evolutionary patterns that are consistent with partner fidelity and long-term associations. We compared gut fungal profiles across natural populations of humans and nonhuman primates and identified significant degrees of primate-mycobiome phylosymbiosis as well as human- enriched fungal taxa. Notably, subsets of fungi are cophylogenetic and exhibit cospeciation patterns in hominids. These findings cautiously originate a new view on the eco-evolutionary potential that can shape the composition of human and primate gut mycobiomes.

Original language	English (US)
Article number	e3003390
Journal	PLoS biology
DOIs	https://doi.org/10.1371/journal.pbio.3003390
State	Published - Sep 2025

Bibliographical note

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Copyright: © 2025 Van Syoc et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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abstract = "Fungi in the gut microbiome, collectively known as the mycobiome, are a prevalent yet neglected component of the human holobiont. A major question in the study of gut microbial communities is whether fungi exhibit eco-evolutionary patterns that are consistent with partner fidelity and long-term associations. We compared gut fungal profiles across natural populations of humans and nonhuman primates and identified significant degrees of primate-mycobiome phylosymbiosis as well as human- enriched fungal taxa. Notably, subsets of fungi are cophylogenetic and exhibit cospeciation patterns in hominids. These findings cautiously originate a new view on the eco-evolutionary potential that can shape the composition of human and primate gut mycobiomes.",

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N1 - Publisher Copyright: Copyright: © 2025 Van Syoc et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Gut fungal profiles reveal phylosymbiosis and codiversification across humans and nonhuman primates

Abstract

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