Guillain-Barre syndrome in immunocompromised patients: A report of three patients and review of the literature

Adnan I. Qureshi, Alberta Cook, Husham P. Mishu, David A. Krendel

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Both humoral and cell-mediated autoimmune mechanisms have been implicated in the pathogenesis of Guillain-Barre syndrome (GBS). Therefore, its occurrence in severely immunocompromised patients is not expected. We identified 3 severely immunocompromised patients who developed GBS. Two of the 3 patients had acquired immunodeficiency syndrome with CD4 counts of 5 and 4 cells/mm3, respectively. One post-cardiac transplant patient was taking azathioprine and cyclosporine at the time of onset of GBS. In all 3 patients, immunocompromise was induced by infectious or chemotherapeutic agents which preferentially suppress T-lymphocyte responses. All 3 had severe lymphocytopenia and incomplete recovery. We conclude that GBS can occur in patients with severe t-cell suppression. Although no conclusion regarding prognosis can be drawn from our small group of patients, their incomplete recovery is consistent with the idea that T-cells are important for recovery.

Original languageEnglish (US)
Pages (from-to)1002-1007
Number of pages6
JournalMuscle and Nerve
Volume20
Issue number8
DOIs
StatePublished - 1997

Keywords

  • Acquired immunodeficiency syndrome
  • Guillain-Barre
  • Immunocompromise

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