Guidelines for Infection Prophylaxis, Monitoring and Therapy in Cord Blood Transplantation

American Society for Transplantation and Cellular Therapy Cord Blood Special Interest Group

Research output: Contribution to journalArticlepeer-review

Abstract

As an alternative stem cell source, cord blood (CB) has many advantages. However, delayed engraftment, lack of transferred immunity, and a significant incidence of acute graft-versus-host disease renders CB transplant (CBT) recipients at high risk of infectious complications. This guidance written by CBT and infectious disease experts outlines evidence-based recommendations for the prevention and treatment of opportunistic infections in adult patients undergoing CBT. Topics addressed include bacterial, fungal, viral, pneumocystis jirovcii and toxoplasmosis prophylaxis, suggested PCR monitoring for viruses, therapy for the most commonly encountered infections after CBT. We review key concepts including the recent important role of letermovir in the prevention of CMV reactivation. In instances where there is a paucity of data, practice recommendations are provided, including the duration of antimicrobial prophylaxis.

Original languageEnglish (US)
Pages (from-to)359-362
Number of pages4
JournalTransplantation and Cellular Therapy
Volume27
Issue number5
DOIs
StatePublished - May 1 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2021 The American Society for Transplantation and Cellular Therapy

Keywords

  • blood transplantation
  • cbt
  • cord
  • infection prophylaxis

PubMed: MeSH publication types

  • Practice Guideline
  • Review

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