Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*

E. A. Olsen; M. Harries; A. Tosti; W. Bergfeld; U. Blume-Peytavi; V. Callender; V. Chasapi; O. Correia; G. Cotsarelis; R. Dhurat; N. Dlova; I. Doche; N. Enechukwu; R. Grimalt; S. Itami; M. Hordinsky; K. Khobzei; W. S. Lee; S. Malakar; A. Messenger; A. McMichael; P. Mirmirani; Y. Ovcharenko; S. Papanikou; G. M. Pinto; B. M. Piraccini; R. Pirmez; P. Reygagne; J. Roberts; L. Rudnicka; D. Saceda-Corralo; J. Shapiro; T. Silyuk; R. Sinclair; R. O. Soares; A. Souissi; A. Vogt; K. Washenik; A. Zlotogorski; D. Canfield; S. Vano-Galvan

doi:10.1111/bjd.20567

Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*

E. A. Olsen, M. Harries, A. Tosti, W. Bergfeld, U. Blume-Peytavi, V. Callender, V. Chasapi, O. Correia, G. Cotsarelis, R. Dhurat, N. Dlova, I. Doche, N. Enechukwu, R. Grimalt, S. Itami, M. Hordinsky, K. Khobzei, W. S. Lee, S. Malakar, A. MessengerA. McMichael, P. Mirmirani, Y. Ovcharenko, S. Papanikou, G. M. Pinto, B. M. Piraccini, R. Pirmez, P. Reygagne, J. Roberts, L. Rudnicka, D. Saceda-Corralo, J. Shapiro, T. Silyuk, R. Sinclair, R. O. Soares, A. Souissi, A. Vogt, K. Washenik, A. Zlotogorski, D. Canfield, S. Vano-Galvan

Dermatology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.

Original language	English (US)
Pages (from-to)	1221-1231
Number of pages	11
Journal	British Journal of Dermatology
Volume	185
Issue number	6
Early online date	Jun 9 2021
DOIs	https://doi.org/10.1111/bjd.20567
State	Published - Aug 13 2021

Bibliographical note

Funding Information:
sources Duke University Hair Research Fund and the Foundation for the Advancement of Hair Disorders.

Publisher Copyright:
© 2021 British Association of Dermatologists

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10.1111/bjd.20567

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Olsen, E. A., Harries, M., Tosti, A., Bergfeld, W., Blume-Peytavi, U., Callender, V., Chasapi, V., Correia, O., Cotsarelis, G., Dhurat, R., Dlova, N., Doche, I., Enechukwu, N., Grimalt, R., Itami, S., Hordinsky, M., Khobzei, K., Lee, W. S., Malakar, S., ... Vano-Galvan, S. (2021). Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*. British Journal of Dermatology, 185(6), 1221-1231. https://doi.org/10.1111/bjd.20567

Olsen, EA, Harries, M, Tosti, A, Bergfeld, W, Blume-Peytavi, U, Callender, V, Chasapi, V, Correia, O, Cotsarelis, G, Dhurat, R, Dlova, N, Doche, I, Enechukwu, N, Grimalt, R, Itami, S, Hordinsky, M, Khobzei, K, Lee, WS, Malakar, S, Messenger, A, McMichael, A, Mirmirani, P, Ovcharenko, Y, Papanikou, S, Pinto, GM, Piraccini, BM, Pirmez, R, Reygagne, P, Roberts, J, Rudnicka, L, Saceda-Corralo, D, Shapiro, J, Silyuk, T, Sinclair, R, Soares, RO, Souissi, A, Vogt, A, Washenik, K, Zlotogorski, A, Canfield, D & Vano-Galvan, S 2021, 'Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*', British Journal of Dermatology, vol. 185, no. 6, pp. 1221-1231. https://doi.org/10.1111/bjd.20567

@article{f40b1c22b1b7434cbd711c8aa2524611,

title = "Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*",

abstract = "Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.",

author = "Olsen, {E. A.} and M. Harries and A. Tosti and W. Bergfeld and U. Blume-Peytavi and V. Callender and V. Chasapi and O. Correia and G. Cotsarelis and R. Dhurat and N. Dlova and I. Doche and N. Enechukwu and R. Grimalt and S. Itami and M. Hordinsky and K. Khobzei and Lee, {W. S.} and S. Malakar and A. Messenger and A. McMichael and P. Mirmirani and Y. Ovcharenko and S. Papanikou and Pinto, {G. M.} and Piraccini, {B. M.} and R. Pirmez and P. Reygagne and J. Roberts and L. Rudnicka and D. Saceda-Corralo and J. Shapiro and T. Silyuk and R. Sinclair and Soares, {R. O.} and A. Souissi and A. Vogt and K. Washenik and A. Zlotogorski and D. Canfield and S. Vano-Galvan",

note = "Funding Information: sources Duke University Hair Research Fund and the Foundation for the Advancement of Hair Disorders. Publisher Copyright: {\textcopyright} 2021 British Association of Dermatologists",

year = "2021",

month = aug,

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doi = "10.1111/bjd.20567",

language = "English (US)",

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TY - JOUR

T1 - Guidelines for clinical trials of frontal fibrosing alopecia

T2 - consensus recommendations from the International FFA Cooperative Group (IFFACG)*

AU - Olsen, E. A.

AU - Harries, M.

AU - Tosti, A.

AU - Bergfeld, W.

AU - Blume-Peytavi, U.

AU - Callender, V.

AU - Chasapi, V.

AU - Correia, O.

AU - Cotsarelis, G.

AU - Dhurat, R.

AU - Dlova, N.

AU - Doche, I.

AU - Enechukwu, N.

AU - Grimalt, R.

AU - Itami, S.

AU - Hordinsky, M.

AU - Khobzei, K.

AU - Lee, W. S.

AU - Malakar, S.

AU - Messenger, A.

AU - McMichael, A.

AU - Mirmirani, P.

AU - Ovcharenko, Y.

AU - Papanikou, S.

AU - Pinto, G. M.

AU - Piraccini, B. M.

AU - Pirmez, R.

AU - Reygagne, P.

AU - Roberts, J.

AU - Rudnicka, L.

AU - Saceda-Corralo, D.

AU - Shapiro, J.

AU - Silyuk, T.

AU - Sinclair, R.

AU - Soares, R. O.

AU - Souissi, A.

AU - Vogt, A.

AU - Washenik, K.

AU - Zlotogorski, A.

AU - Canfield, D.

AU - Vano-Galvan, S.

PY - 2021/8/13

Y1 - 2021/8/13

N2 - Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.

AB - Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.

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SN - 0007-0963

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JO - British Journal of Dermatology

JF - British Journal of Dermatology

IS - 6

ER -

Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*

Abstract

Bibliographical note

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