Guidelines for clinical trials of frontal fibrosing alopecia: consensus recommendations from the International FFA Cooperative Group (IFFACG)*

E. A. Olsen, M. Harries, A. Tosti, W. Bergfeld, U. Blume-Peytavi, V. Callender, V. Chasapi, O. Correia, G. Cotsarelis, R. Dhurat, N. Dlova, I. Doche, N. Enechukwu, R. Grimalt, S. Itami, M. Hordinsky, K. Khobzei, W. S. Lee, S. Malakar, A. MessengerA. McMichael, P. Mirmirani, Y. Ovcharenko, S. Papanikou, G. M. Pinto, B. M. Piraccini, R. Pirmez, P. Reygagne, J. Roberts, L. Rudnicka, D. Saceda-Corralo, J. Shapiro, T. Silyuk, R. Sinclair, R. O. Soares, A. Souissi, A. Vogt, K. Washenik, A. Zlotogorski, D. Canfield, S. Vano-Galvan

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Background: Frontal fibrosing alopecia (FFA) has become one of the most common causes of cicatricial alopecia worldwide. However, there is a lack of clear aetiology and robust clinical trial evidence for the efficacy and safety of agents currently used for treatment. Objectives: To enable data to be collected worldwide on FFA using common criteria and assessment methods. Methods: A multicentre, international group of experts in hair loss was convened by email to create consensus recommendations for clinical trials. Consensus was defined at > 90% agreement on each recommended part of these guidelines. Results: Standardized diagnostic criteria, severity rating, staging, and investigator and patient assessment of scalp hair loss and other clinical features of FFA were created. Conclusions: These guidelines should allow the collection of reliable aggregate data on FFA and advance efforts in both clinical and basic research to close knowledge gaps in this condition.

Original languageEnglish (US)
Pages (from-to)1221-1231
Number of pages11
JournalBritish Journal of Dermatology
Volume185
Issue number6
Early online dateJun 9 2021
DOIs
StatePublished - Aug 13 2021

Bibliographical note

Funding Information:
sources Duke University Hair Research Fund and the Foundation for the Advancement of Hair Disorders.

Publisher Copyright:
© 2021 British Association of Dermatologists

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