Guanylyl cyclase structure, function and regulation

Research output: Contribution to journalReview article

137 Citations (Scopus)

Abstract

Nitric oxide, bicarbonate, natriuretic peptides (ANP, BNP and CNP), guanylins, uroguanylins and guanylyl cyclase activating proteins (GCAPs) activate a family of enzymes variously called guanyl, guanylyl or guanylate cyclases that catalyze the conversion of guanosine triphosphate to cyclic guanosine monophosphate (cGMP) and pyrophosphate. Intracellular cyclic GMP is a second messenger that modulates: platelet aggregation, neurotransmission, sexual arousal, gut peristalsis, blood pressure, long bone growth, intestinal fluid secretion, lipolysis, phototransduction, cardiac hypertrophy and oocyte maturation. This review briefly discusses the discovery of cGMP and guanylyl cyclases, then nitric oxide, nitric oxide synthase and soluble guanylyl cyclase are described in slightly greater detail. Finally, the structure, function, and regulation of the individual mammalian single membrane-spanning guanylyl cyclases GC-A, GC-B, GC-C, GC-D, GC-E, GC-F and GC-G are described in greatest detail as determined by biochemical, cell biological and gene-deletion studies.

Original languageEnglish (US)
Pages (from-to)1921-1926
Number of pages6
JournalCellular Signalling
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2011

Fingerprint

Guanylate Cyclase
Cyclic GMP
Guanylate Cyclase-Activating Proteins
Nitric Oxide
Light Signal Transduction
Intestinal Secretions
Fluids and Secretions
Peristalsis
Natriuretic Peptides
Lipolysis
Bone Development
Gene Deletion
Cardiomegaly
Atrial Natriuretic Factor
Second Messenger Systems
Bicarbonates
Guanosine Triphosphate
Arousal
Platelet Aggregation
Nitric Oxide Synthase

Keywords

  • CGMP
  • Enzymes
  • Hormones
  • Signal transduction

Cite this

Guanylyl cyclase structure, function and regulation. / Potter, Lincoln R.

In: Cellular Signalling, Vol. 23, No. 12, 01.12.2011, p. 1921-1926.

Research output: Contribution to journalReview article

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