Guanosine 5' diphosphate, 3' diphosphate: Assignment of structure by 13C nuclear magnetic resonance spectroscopy

L. Que, G. R. Willie, M. Cashel, J. W. Bodley, G. R. Gray

Research output: Contribution to journalArticle

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Abstract

Guanosine tetraphosphate, recently discovered to mediate the regulatory relationship between protein synthesis and RNA accumulation in various bacteria, has been synthesized in vitro in large quantities and analyzed by natural abundance 13C nuclear magnetic resonance spectroscopy in order to confirm its structure and establish the positions of phosphate attachment. These studies have established its structure as guanosine 5' diphosphate, 3' diphosphate.

Original languageEnglish (US)
Pages (from-to)2563-2566
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume70
Issue number9
DOIs
StatePublished - Dec 1 1973

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