Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments

S. A. Krumins; D. C. Kim; O. J. Igwe; A. A. Larson

Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments

S. A. Krumins, D. C. Kim, O. J. Igwe, A. A. Larson

Veterinary and Biomedical Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Studies, designed to delineate the portions of substance P (SP) molecule needed for reversal of GppNHP-induced inhibition of DAMGO binding, have shown that nanomolar concentrations of SP fragments containing the N-terminus of SP reduce both the K(d) and B(max) values of DAMGO binding to a high-affinity site.

Original language	English (US)
Title of host publication	New leads in opioid research
Subtitle of host publication	proceedings of the International Narcotics Research Conference. ICS914
Editors	J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus, J.M. Van Ree, A.H. Mulder, V.M. Wiegant, T.B. Van Wimersma Greidanus
Publisher	Elsevier Science Publishers B.V.
Pages	163-165
Number of pages	3
ISBN (Print)	044481213X
State	Published - Jan 1 1990
Event	The International Narcotics Research Conference - Duration: Jul 8 1989 → Jul 13 1989

Publication series

Name	New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914

Other

Other	The International Narcotics Research Conference
Period	7/8/89 → 7/13/89

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Krumins, S. A., Kim, D. C., Igwe, O. J., & Larson, A. A. (1990). Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments. In J. M. Van Ree, A. H. Mulder, V. M. Wiegant, T. B. Van Wimersma Greidanus, J. M. Van Ree, A. H. Mulder, V. M. Wiegant, & T. B. Van Wimersma Greidanus (Eds.), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914 (pp. 163-165). (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914). Elsevier Science Publishers B.V..

Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments. / Krumins, S. A.; Kim, D. C.; Igwe, O. J. et al.
New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. ed. / J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus; J.M. Van Ree; A.H. Mulder; V.M. Wiegant; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. p. 163-165 (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Krumins, SA, Kim, DC, Igwe, OJ & Larson, AA 1990, Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments. in JM Van Ree, AH Mulder, VM Wiegant, TB Van Wimersma Greidanus, JM Van Ree, AH Mulder, VM Wiegant & TB Van Wimersma Greidanus (eds), New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914, Elsevier Science Publishers B.V., pp. 163-165, The International Narcotics Research Conference, 7/8/89.

Krumins SA, Kim DC, Igwe OJ, Larson AA. Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments. In Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, Van Ree JM, Mulder AH, Wiegant VM, Van Wimersma Greidanus TB, editors, New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. Elsevier Science Publishers B.V. 1990. p. 163-165. (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914).

Krumins, S. A. ; Kim, D. C. ; Igwe, O. J. et al. / Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments. New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914. editor / J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus ; J.M. Van Ree ; A.H. Mulder ; V.M. Wiegant ; T.B. Van Wimersma Greidanus. Elsevier Science Publishers B.V., 1990. pp. 163-165 (New leads in opioid research: proceedings of the International Narcotics Research Conference. ICS914).

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abstract = "Studies, designed to delineate the portions of substance P (SP) molecule needed for reversal of GppNHP-induced inhibition of DAMGO binding, have shown that nanomolar concentrations of SP fragments containing the N-terminus of SP reduce both the K(d) and B(max) values of DAMGO binding to a high-affinity site.",

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AU - Kim, D. C.

AU - Igwe, O. J.

AU - Larson, A. A.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Studies, designed to delineate the portions of substance P (SP) molecule needed for reversal of GppNHP-induced inhibition of DAMGO binding, have shown that nanomolar concentrations of SP fragments containing the N-terminus of SP reduce both the K(d) and B(max) values of DAMGO binding to a high-affinity site.

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EP - 165

BT - New leads in opioid research

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A2 - Mulder, A.H.

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A2 - Mulder, A.H.

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PB - Elsevier Science Publishers B.V.

T2 - The International Narcotics Research Conference

Y2 - 8 July 1989 through 13 July 1989

ER -

Guanine nucleotide inhibition of DAMGO binding in the mouse brain, as modified by substance P and its fragments

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