GTP (γS) and GDP (βS) as electron donors: New wine in old bottles

Douglas A Peterson, Daniel C. Peterson, Helen L. Reeve, Stephen L. Archer, Edward K Weir

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


G proteins are membrane-bound regulatory proteins which modulate the activity of ion channels and other effector systems. The GTP and GDP analogs GTP (γS) and GDP (βS) have been used to study the role of G proteins in numerous physiologic systems. The prolonged effects of these analogs have been thought to be due to the fact that they are nonhydrolyzable. However, in this paper we show that the GTP (γS) and GDP (βS) analogs are potent reducing agents at physiologic pH. This observation suggests that previous data obtained using these compounds may need to be reinterpreted.

Original languageEnglish (US)
Pages (from-to)1135-1140
Number of pages6
JournalLife Sciences
Issue number11
StatePublished - Aug 6 1999

Bibliographical note

Funding Information:
This work was supported by VA Merit Review Research Funding of E. Kenneth Weir.


  • G proteins
  • GDP (βS)
  • GTP (γS)
  • Ion channels
  • Receptors
  • Redox


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