Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone

Alejandro López-Juárez, Jennifer Howard, Kristy Ullom, Lindsey Howard, Andrew Grande, Andrea Pardo, Ronald Waclaw, Yu Yo Sun, Dianer Yang, Chia Yi Kuan, Kenneth Campbell, Masato Nakafuku

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Neural stem cells (NSCs) reside in widespread regions along the lateral ventricle and generate diverse olfactory bulb (OB) interneuron subtypes in the adult mouse brain. Molecular mechanisms underlying their regional diversity, however, are not well understood. Here we show that the homeodomain transcription factor Gsx2 plays a crucial role in the region-specific control of adult NSCs in both persistent and injury-induced neurogenesis. In the intact brain, Gsx2 is expressed in a regionally restricted subset of NSCs and promotes the activation and lineage progression of stem cells, thereby controlling the production of selective OB neuron subtypes. Moreover, Gsx2 is ectopically induced in damaged brains outside its normal expression domains and is required for injuryinduced neurogenesis in the subventricular zone (SVZ). These results demonstrate that mobilization of adult NSCs is controlled in a region-specific manner and that distinct mechanisms operate in continuous and injuryinduced neurogenesis in the adult brain.

Original languageEnglish (US)
Pages (from-to)1272-1287
Number of pages16
JournalGenes and Development
Volume27
Issue number11
DOIs
StatePublished - Feb 1 2013

Keywords

  • Adult neurogenesis
  • Injury
  • Regional identity
  • Stem cell
  • Stroke

Fingerprint Dive into the research topics of 'Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone'. Together they form a unique fingerprint.

Cite this