GSH-responsive polymeric micelles based on the thio-ene reaction for controlled drug release

Hongliang Cao, Huajie Song, Debiao Xie, Chao Chen, Xin Chen, Ping Wang, Wenxin Wang

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

We report a glutathione (GSH) responsive drug carrier that is based on the Michael addition reaction between an olefinic bond and GSH. Amphiphilic copolymers with multi-linear-cyclized and branched structures that contain vinyl groups were successfully synthesized by deactivation enhanced atom transfer radical polymerization (DE-ATRP). The polymers self-assembled into GSH responsive micelles with sizes of 68 to 97 nm and spherical morphology. The core cross-linked micelles were confirmed to greatly decrease doxorubicin (DOX) leakage due to the concentration gradient. Drug release experiments indicated that the drug carrier containing no disulfide has the same responsive ability as a conventional GSH reduction responsive carrier with a similar polymer structure. MTT assays showed that the blank micelles are totally non-cytotoxic, while the DOX-loaded micelles exhibit GSH-dependent behaviour.

Original languageEnglish (US)
Pages (from-to)80896-80904
Number of pages9
JournalRSC Advances
Volume6
Issue number84
DOIs
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2016 The Royal Society of Chemistry.

Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.

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