Growth stimulation of ferritin of human leukemia cells in vitro

Nobuaki Kikyo, Koichi Hagiwara, Yoshio Yazaki, Tetsuro Okabe

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Ferritin has been reported to inhibit the growth of some leukemia cells in serum-supplemented culture. Recently we have found that ferritin stimulates the proliferation of human acute myeloblastic leukemia cells HL-60 and erythroleukemia cells K-562-T1 in serum-free medium. In this study, we examined the effect of ferritin against 14 human leukemia cell lines using human heart ferritin in serum-depleted culture medium. Among 14 cell lines tested, 10 were stimulated to proliferate by ferritin (maximum response at 30-300 ng/ml) with 0-1% fetal calf serum (FCS). The growth of all the cell lines was significantly inhibited by ferritin in the presence of 10% FCS. These results suggest that ferritin has dual functions; it promotes the growth of leukemia cells with low concentrations of FCS, but suppresses their growth with high concentrations of FCS.

Original languageEnglish (US)
Pages (from-to)76-78
Number of pages3
JournalJournal of Cancer Research and Clinical Oncology
Issue number2
StatePublished - Feb 1 1995


  • Ferritin
  • Growth inhibition
  • Growth promotion
  • Leukemia cells
  • Serum concentration


Dive into the research topics of 'Growth stimulation of ferritin of human leukemia cells in vitro'. Together they form a unique fingerprint.

Cite this