Growth performance and carcass composition of lambs infused for 28 days with a growth hormone-releasing factor analogue.

J. A. Godfredson, J. E. Wheaton, Brian A Crooker, E. A. Wong, R. M. Campbell, T. F. Mowles

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

A human growth hormone-releasing factor analogue, [DesNH2Tyr1,D-Ala2,Ala15]hGRF(1-29)NH2 (GRF-A), was infused s.c. into lambs for 28 d to determine its effects on growth performance and carcass composition. Twenty crossbred wethers weighing 47.0 +/- .5 kg were implanted with 7-d osmotic minipumps at weekly intervals. Minipumps contained either vehicle (dimethyl sulfoxide:H2O, 1:1) or GRF-A, released at a rate of 208 pmol (or .7 micrograms).h-1.kg-1. During the infusion period, plasma GH levels were increased (P less than .01) in GRF-A-treated wethers compared with control wethers (15.0 vs 9.3 ng/ml) and were higher on days that closely followed minipump implantation. Plasma IGF-I and hepatic IGF-I RNA concentrations were similar in lambs of both groups. Analogue treatment improved feed conversion (4.9 vs 5.8 kg dry matter/kg gain, P less than .05), increased average daily gain (.35 vs .30 kg, P = .05) and had no effect on feed intake, wool growth and body, carcass, selected organ and pituitary weights. Carcasses from GRF-A-infused lambs had less adjusted fat depth, a lower percentage of fat and a higher percentage of protein (P less than .05) than carcasses from control lambs. Magnitude of most effects of GRF-A on carcass measurements were correlated with the mean GH level that a lamb had during the infusion period. In conclusion, s.c. infusion of GRF-A improved feed utilization and altered carcass composition of feeder lambs in a relatively short period of time (28 d).

Original languageEnglish (US)
Pages (from-to)3624-3632
Number of pages9
JournalJournal of animal science
Volume68
Issue number11
DOIs
StatePublished - Nov 1990

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