Growth patterns and the use of growth hormone in the mucopolysaccharidoses

Lynda E. Polgreen, B. S. Miller

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Short stature is characteristic of patients with mucopolysaccharidosis (MPS) diseases. For children with skeletal dysplasias, such as MPS, it is important to know the natural history of growth. An understanding of the natural growth pattern in each MPS disease provides a measurement to which treatments can be compared, as well as data which can help families and providers make individualized decisions about growth promoting treatments. Multiple advancements have been made in the treatment of MPS with both hematopoietic cell transplantation (HCT) and enzyme replacement therapy (ERT). The long term benefit of these treatments on growth is unknown. This article will review the published data on growth in children with MPS, and describe preliminary data on the use of human growth hormone (hGH) in children with MPS.

Original languageEnglish (US)
Pages (from-to)25-38
Number of pages14
JournalJournal of Pediatric Rehabilitation Medicine
Issue number1
StatePublished - 2010


  • Endocrine disease
  • Growth
  • Growth hormone
  • MPS
  • Mucopolysaccharidoses


Dive into the research topics of 'Growth patterns and the use of growth hormone in the mucopolysaccharidoses'. Together they form a unique fingerprint.

Cite this