Growth hormone treatment

Brandon M. Nathan, David B. Allen

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Human growth hormone (GH) was first used more than 30 years ago to stimulate growth in a child with hypopituitarism (1). Subsequently, a limited supply of pituitary glands from which GH could be extracted and purified required that GH therapy be restricted to children with the most severe and unequivocal GH deficiency (GHD). Strict, arbitrary laboratory criteria were established to identify patients likely to derive the greatest benefit from scarce GH. Delays in diagnosis and treatment, interruptions in therapy, and dosage restrictions were common during this time. Consequently, while GH accelerated growth of these individuals, adult statures were usually less than average (2-4).

Original languageEnglish (US)
Title of host publicationPediatric Endocrinology, Fifth Edition
Subtitle of host publicationVolume 2 Growth, Adrenal, Sexual, Thyroid, Calcium, and Fluid Balance Disorders
PublisherCRC Press
Pages113-143
Number of pages31
ISBN (Electronic)9781420042726
ISBN (Print)9781420042702
StatePublished - Jan 1 2006
Externally publishedYes

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