Growth hormone therapy in children; research and practice – A review

Paulo Ferrez Collett-Solberg, Alexander A.L. Jorge, Margaret C.S. Boguszewski, Bradley S. Miller, Catherine Seut Yhoke Choong, Pinchas Cohen, Andrew R. Hoffman, Xiaoping Luo, Sally Radovick, Paul Saenger

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


Short stature remains the most common reason for referral to a pediatric Endocrinologist and its management remains a challenge. One of the main controversies is the diagnosis of idiopathic short stature and the role of new technologies for genetic investigation of children with inadequate growth. Complexities in management of children with short stature includes selection of who should receive interventions such as recombinant human growth hormone, and how should this agent dose be adjusted during treatment. Should anthropometrical data be the primary determinant or should biochemical and genetic data be used to improve growth response and safety? Furthermore, what is considered a suboptimal response to growth hormone therapy and how should this be managed? Treatment of children with short stature remains a “hot” topic and more data is needed in several areas. These issues are reviewed in this paper.

Original languageEnglish (US)
Pages (from-to)20-32
Number of pages13
JournalGrowth Hormone and IGF Research
StatePublished - Feb 2019

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd


  • Genetic
  • Growth
  • Growth hormone
  • Short stature


Dive into the research topics of 'Growth hormone therapy in children; research and practice – A review'. Together they form a unique fingerprint.

Cite this