Group-biomarkers identification in ovarian carcinoma

Alain B. Tchagang, Ahmed H. Tewfik, Amy P.N. Skubitz, Keith Skubitz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

In this paper, we propose group-biomarkers as an alternative to the traditional single biomarkers used to date for the detection of ovarian cancer. Group-biomarkers are a set of genes that are used simultaneously for the diagnosis of early-stage and/or recurrent cancer, We describe a procedure for identifying such group-biomarkers from a data set of gene expression levels corresponding to normal and diseased ovarian tissue as well as tissue from other organs. The procedure starts with a list of potential single biomarkers. It then uses an order preserving biclustering step to identify other genes that are co-regulated with the candidate single, biomarkers across the normal and diseased ovarian tissue and, tissue from other organ. We present a statistical analysis that demonstrates that group-biomarkers have a much better detection performance than single hiomarkers as exhibited by receiver operating characteristics curves.

Original languageEnglish (US)
Title of host publication2007 IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP '07
PagesI341-I344
DOIs
StatePublished - Aug 6 2007
Event2007 IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP '07 - Honolulu, HI, United States
Duration: Apr 15 2007Apr 20 2007

Publication series

NameICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
Volume1
ISSN (Print)1520-6149

Other

Other2007 IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP '07
CountryUnited States
CityHonolulu, HI
Period4/15/074/20/07

Keywords

  • Biclustering
  • Biomarkers
  • DNA microarray
  • Ovarian cancer

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  • Cite this

    Tchagang, A. B., Tewfik, A. H., Skubitz, A. P. N., & Skubitz, K. (2007). Group-biomarkers identification in ovarian carcinoma. In 2007 IEEE International Conference on Acoustics, Speech and Signal Processing, ICASSP '07 (pp. I341-I344). [4217086] (ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings; Vol. 1). https://doi.org/10.1109/ICASSP.2007.366686