Group B streptococci causing neonatal bloodstream infection: Antimicrobial susceptibility and serotyping results from SENTRY centers in the Western Hemisphere

Janet I. Andrews, Daniel J. Diekema, Stephen K. Hunter, Paul R. Rhomberg, Michael A. Pfaller, Ronald N. Jones, Gary V. Doern

Research output: Contribution to journalArticlepeer-review

99 Scopus citations


OBJECTIVE: Group B streptococcal infection is a common cause of neonatal sepsis. Surveillance of antimicrobial susceptibility and serotype frequencies of invasive group B streptococci is important to ensure the effectiveness of therapeutic regimens and to guide vaccine development. STUDY DESIGN: Prospective surveillance of neonatal bloodstream infection was performed at all Western Hemisphere sites participating in the SENTRY Program. From January 1997 through December 1999, a total of 122 isolates of bloodstream infections with group B streptococci were collected and sent to the University of Iowa for antimicrobial susceptibility testing and serotyping. RESULTS: No isolates were resistant to penicillin. More than 25% of isolates from US hospitals and 14% of isolates from Canadian hospitals were erythromycin resistant. Seven percent of isolates from the United States and Canada were resistant to clindamycin. No clindamycin or erythromycin resistance was found among isolates from Latin America. Clindamycin and erythromycin resistance was most frequent among serotype V strains. CONCLUSIONS: No emerging resistance to penicillin was noted among bloodstream infection isolates of group B streptococci from a broad geographic area; erythromycin and clindamycin resistance was found in the United States and Canada and appeared most frequently among serotype V strains.

Original languageEnglish (US)
Pages (from-to)859-862
Number of pages4
JournalAmerican journal of obstetrics and gynecology
Issue number4
StatePublished - 2000
Externally publishedYes

Bibliographical note

Funding Information:
From the Department of Obstetrics and Gynecology,a the Division of Infectious Diseases, Department of Internal Medicine,b and the Division of Medical Microbiology, Department of Pathology,c University of Iowa College of Medicine. Supported in part by a research and educational grant from Bristol-Myers Squibb. Presented at the Twentieth Annual Meeting of the Society for Maternal-Fetal Medicine, Miami Beach, Florida, January 31–February 5, 2000. Reprint requests: Janet I. Andrews, MD, Department of Obstetrics and Gynecology, University of Iowa College of Medicine, SW 44-14 GH, 200 Hawkins Dr, Iowa City, IA 52242. Copyright © 2000 by Mosby, Inc. 0002-9378/2000 $12.00 + 0 6/6/108839 doi:10.1067/mob.2000.108839

Copyright 2017 Elsevier B.V., All rights reserved.


  • Antimicrobial resistance
  • Group B streptococci
  • Surveillance


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