Green Light Exposure Elicits Anti-inflammation, Endogenous Opioid Release and Dampens Synaptic Potentiation to Relieve Post-surgical Pain

Laurent F. Martin, Kevin Cheng, Stephanie M. Washington, Millie Denton, Vasudha Goel, Maithili Khandekar, Tally M. Largent-Milnes, Amol Patwardhan, Mohab M. Ibrahim

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Light therapy improves multiple conditions such as seasonal affective disorders, circadian rhythm dysregulations, and neurodegenerative diseases. However, little is known about its potential benefits in pain management. While current pharmacologic methods are effective in many cases, the associated side effects can limit their use. Non-pharmacological methods would minimize drug dependence, facilitating a reduction of the opioid burden. Green light therapy has been shown to be effective in reducing chronic pain in humans and rodents. However, its underlying mechanisms remain incompletely defined. In this study, we demonstrate that green light exposure reduced postsurgical hypersensitivity in rats. Moreover, this therapy potentiated the antinociceptive effects of morphine and ibuprofen on mechanical allodynia in male rats. Importantly, in female rats, GLED potentiated the antinociceptive effects of morphine but did not affect that of ibuprofen. We showed that green light increases endogenous opioid levels while lessening synaptic plasticity and neuroinflammation. Importantly, this study reveals new insights into how light exposure can affect neuroinflammation and plasticity in both genders. Clinical translation of these results could provide patients with improved pain control and decrease opioid consumption. Given the noninvasive nature of green light, this innovative therapy would be readily implementable in hospitals. Perspective: This study provides a potential additional therapy to decrease postsurgical pain. Given the safety, availability, and the efficacy of green light therapy, there is a significant potential for advancing the green light therapy to clinical trials and eventual translation to clinical settings.

Original languageEnglish (US)
Pages (from-to)509-529
Number of pages21
JournalJournal of Pain
Volume24
Issue number3
DOIs
StatePublished - Mar 2023

Bibliographical note

Funding Information:
Grant information: This work was supported by the National Center for Complementary and Integrative Health [R01AT009716, 2018] (M.M.I.), National Institutes of Health [K08 NS104272, 2018] (A.P.), the University of Arizona CHiLLi Initiative (M.M.I.), and the University of Arizona Comprehensive Pain and Addiction Center (M.M.I.)

Publisher Copyright:
© 2022 United States Association for the Study of Pain, Inc.

Keywords

  • Endogenous opioid
  • GLED phototherapy
  • Neuroinflammation
  • Plasticity
  • Postsurgical pain

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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