Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study

Samar R. El Khoudary; Xirun Chen; Alexis Nasr; Kelly Shields; Emma Barinas-Mitchel; Imke Janssen; Susan Everson-Rose; Lynda H. Powell; Karen A. Matthews

doi:10.1093/gerona/glz095

Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study

Samar R. El Khoudary, Xirun Chen , Alexis Nasr, Kelly Shields, Emma Barinas-Mitchel, Imke Janssen, Susan Everson-Rose, Lynda H. Powell, Karen A. Matthews

Medicine - Geriatrics, Palliative and Primary Care (GPPC)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

BACKGROUND: Higher perivascular adipose tissue (PVAT) contributes to adverse physiologic alterations in the vascular wall, and thus could potentially limit normal physical function later in life. We hypothesize that higher PVAT volume at midlife is prospectively associated with slower gait speed later in life, independent of overall adiposity and other risk factors. METHODS: Participants from the Study of Women's Health Across the Nation (SWAN) cardiovascular fat ancillary study were included. PVAT volume around the descending aorta was quantified using existing computed tomography scans at midlife, while gait speed was measured after an average of 10.4 ± 0.7 years. RESULTS: Two hundred and seventy-six women (aged 51.3 ± 2.8 years at PVAT assessment) were included. Mean gait speed was 0.96 ± 0.21 m/s. Adjusting for study site, race, education level, menopausal status, and length of descending aorta at PVAT assessment, and age, body mass index, difficulty paying for basics, overall health and smoking status at gait speed assessment, a higher midlife PVAT volume was associated with a slower gait speed later in life (p = .03). With further adjustment for presence of any comorbid conditions by the time of gait speed assessment, the association persisted; every 1SD increase in log-PVAT was associated with 3.3% slower gait speed (95% confidence interval: 0.3-6.3%; p = .03). CONCLUSION: Greater PVAT in midlife women may contribute to poorer physical function in older age supporting a potential role of midlife PVAT in multiple domains of healthy aging. Additional research is needed to fully elucidate the physiologic changes associated with PVAT that may underlie the observed associations.

Original language	English (US)
Pages (from-to)	1959-1964
Number of pages	6
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	74
Issue number	12
Early online date	Apr 12 2019
DOIs	https://doi.org/10.1093/gerona/glz095
State	Published - Nov 13 2019

Bibliographical note

Funding Information:
This work was supported by an award from the American Heart Association Great River Affiliation Clinical Research Program: 12CRP11900031 (SWAN Cardiovascular Fat Ancillary Study). The Study of Women’s Health Across the Nation (SWAN) has grant support from the National Institutes of Health (NIH); DHHS, through the National Institute on Aging (NIA); the National Institute of Nursing Research (NINR); and the NIH Office of Research on Women’s Health (ORWH) (grants U01NR004061, U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495). SWAN Heat was supported by the National Heart, Lung and Blood Institute (grants HL065581, HL065591). The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIA, NINR, ORWH, or the NIH.

Publisher Copyright:
© 2019 The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.

Keywords

Midlife
Perivascular adipose tissue
Physical functioning
Walking speed

PubMed: MeSH publication types

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Publisher link

10.1093/gerona/glz095

Find It

Find It at U of M Libraries

Cite this

El Khoudary, S. R., Chen , X., Nasr, A., Shields, K., Barinas-Mitchel, E., Janssen, I., Everson-Rose, S., Powell, L. H., & Matthews, K. A. (2019). Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 74(12), 1959-1964. https://doi.org/10.1093/gerona/glz095

Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women : The SWAN Cardiovascular Fat Ancillary Study. / El Khoudary, Samar R.; Chen , Xirun; Nasr, Alexis et al.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 74, No. 12, 13.11.2019, p. 1959-1964.

Research output: Contribution to journal › Article › peer-review

El Khoudary, SR, Chen , X, Nasr, A, Shields, K, Barinas-Mitchel, E, Janssen, I, Everson-Rose, S, Powell, LH & Matthews, KA 2019, 'Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 74, no. 12, pp. 1959-1964. https://doi.org/10.1093/gerona/glz095

El Khoudary SR, Chen X, Nasr A, Shields K, Barinas-Mitchel E, Janssen I et al. Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study. Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2019 Nov 13;74(12):1959-1964. Epub 2019 Apr 12. doi: 10.1093/gerona/glz095

@article{a1a03fe3c8cf4028a51c81e461f0a328,

title = "Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study",

abstract = "BACKGROUND: Higher perivascular adipose tissue (PVAT) contributes to adverse physiologic alterations in the vascular wall, and thus could potentially limit normal physical function later in life. We hypothesize that higher PVAT volume at midlife is prospectively associated with slower gait speed later in life, independent of overall adiposity and other risk factors. METHODS: Participants from the Study of Women's Health Across the Nation (SWAN) cardiovascular fat ancillary study were included. PVAT volume around the descending aorta was quantified using existing computed tomography scans at midlife, while gait speed was measured after an average of 10.4 ± 0.7 years. RESULTS: Two hundred and seventy-six women (aged 51.3 ± 2.8 years at PVAT assessment) were included. Mean gait speed was 0.96 ± 0.21 m/s. Adjusting for study site, race, education level, menopausal status, and length of descending aorta at PVAT assessment, and age, body mass index, difficulty paying for basics, overall health and smoking status at gait speed assessment, a higher midlife PVAT volume was associated with a slower gait speed later in life (p = .03). With further adjustment for presence of any comorbid conditions by the time of gait speed assessment, the association persisted; every 1SD increase in log-PVAT was associated with 3.3% slower gait speed (95% confidence interval: 0.3-6.3%; p = .03). CONCLUSION: Greater PVAT in midlife women may contribute to poorer physical function in older age supporting a potential role of midlife PVAT in multiple domains of healthy aging. Additional research is needed to fully elucidate the physiologic changes associated with PVAT that may underlie the observed associations.",

keywords = "Midlife, Perivascular adipose tissue, Physical functioning, Walking speed",

author = "{El Khoudary}, {Samar R.} and Xirun Chen and Alexis Nasr and Kelly Shields and Emma Barinas-Mitchel and Imke Janssen and Susan Everson-Rose and Powell, {Lynda H.} and Matthews, {Karen A.}",

note = "Funding Information: This work was supported by an award from the American Heart Association Great River Affiliation Clinical Research Program: 12CRP11900031 (SWAN Cardiovascular Fat Ancillary Study). The Study of Women{\textquoteright}s Health Across the Nation (SWAN) has grant support from the National Institutes of Health (NIH); DHHS, through the National Institute on Aging (NIA); the National Institute of Nursing Research (NINR); and the NIH Office of Research on Women{\textquoteright}s Health (ORWH) (grants U01NR004061, U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495). SWAN Heat was supported by the National Heart, Lung and Blood Institute (grants HL065581, HL065591). The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIA, NINR, ORWH, or the NIH. Publisher Copyright: {\textcopyright} 2019 The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.",

year = "2019",

month = nov,

day = "13",

doi = "10.1093/gerona/glz095",

language = "English (US)",

volume = "74",

pages = "1959--1964",

journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",

issn = "1079-5006",

publisher = "Oxford University Press",

number = "12",

}

TY - JOUR

T1 - Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women

T2 - The SWAN Cardiovascular Fat Ancillary Study

AU - El Khoudary, Samar R.

AU - Chen , Xirun

AU - Nasr, Alexis

AU - Shields, Kelly

AU - Barinas-Mitchel, Emma

AU - Janssen, Imke

AU - Everson-Rose, Susan

AU - Powell, Lynda H.

AU - Matthews, Karen A.

N1 - Funding Information: This work was supported by an award from the American Heart Association Great River Affiliation Clinical Research Program: 12CRP11900031 (SWAN Cardiovascular Fat Ancillary Study). The Study of Women’s Health Across the Nation (SWAN) has grant support from the National Institutes of Health (NIH); DHHS, through the National Institute on Aging (NIA); the National Institute of Nursing Research (NINR); and the NIH Office of Research on Women’s Health (ORWH) (grants U01NR004061, U01AG012505, U01AG012535, U01AG012531, U01AG012539, U01AG012546, U01AG012553, U01AG012554, U01AG012495). SWAN Heat was supported by the National Heart, Lung and Blood Institute (grants HL065581, HL065591). The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of the NIA, NINR, ORWH, or the NIH. Publisher Copyright: © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.

PY - 2019/11/13

Y1 - 2019/11/13

N2 - BACKGROUND: Higher perivascular adipose tissue (PVAT) contributes to adverse physiologic alterations in the vascular wall, and thus could potentially limit normal physical function later in life. We hypothesize that higher PVAT volume at midlife is prospectively associated with slower gait speed later in life, independent of overall adiposity and other risk factors. METHODS: Participants from the Study of Women's Health Across the Nation (SWAN) cardiovascular fat ancillary study were included. PVAT volume around the descending aorta was quantified using existing computed tomography scans at midlife, while gait speed was measured after an average of 10.4 ± 0.7 years. RESULTS: Two hundred and seventy-six women (aged 51.3 ± 2.8 years at PVAT assessment) were included. Mean gait speed was 0.96 ± 0.21 m/s. Adjusting for study site, race, education level, menopausal status, and length of descending aorta at PVAT assessment, and age, body mass index, difficulty paying for basics, overall health and smoking status at gait speed assessment, a higher midlife PVAT volume was associated with a slower gait speed later in life (p = .03). With further adjustment for presence of any comorbid conditions by the time of gait speed assessment, the association persisted; every 1SD increase in log-PVAT was associated with 3.3% slower gait speed (95% confidence interval: 0.3-6.3%; p = .03). CONCLUSION: Greater PVAT in midlife women may contribute to poorer physical function in older age supporting a potential role of midlife PVAT in multiple domains of healthy aging. Additional research is needed to fully elucidate the physiologic changes associated with PVAT that may underlie the observed associations.

AB - BACKGROUND: Higher perivascular adipose tissue (PVAT) contributes to adverse physiologic alterations in the vascular wall, and thus could potentially limit normal physical function later in life. We hypothesize that higher PVAT volume at midlife is prospectively associated with slower gait speed later in life, independent of overall adiposity and other risk factors. METHODS: Participants from the Study of Women's Health Across the Nation (SWAN) cardiovascular fat ancillary study were included. PVAT volume around the descending aorta was quantified using existing computed tomography scans at midlife, while gait speed was measured after an average of 10.4 ± 0.7 years. RESULTS: Two hundred and seventy-six women (aged 51.3 ± 2.8 years at PVAT assessment) were included. Mean gait speed was 0.96 ± 0.21 m/s. Adjusting for study site, race, education level, menopausal status, and length of descending aorta at PVAT assessment, and age, body mass index, difficulty paying for basics, overall health and smoking status at gait speed assessment, a higher midlife PVAT volume was associated with a slower gait speed later in life (p = .03). With further adjustment for presence of any comorbid conditions by the time of gait speed assessment, the association persisted; every 1SD increase in log-PVAT was associated with 3.3% slower gait speed (95% confidence interval: 0.3-6.3%; p = .03). CONCLUSION: Greater PVAT in midlife women may contribute to poorer physical function in older age supporting a potential role of midlife PVAT in multiple domains of healthy aging. Additional research is needed to fully elucidate the physiologic changes associated with PVAT that may underlie the observed associations.

KW - Midlife

KW - Perivascular adipose tissue

KW - Physical functioning

KW - Walking speed

UR - http://www.scopus.com/inward/record.url?scp=85074965236&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85074965236&partnerID=8YFLogxK

U2 - 10.1093/gerona/glz095

DO - 10.1093/gerona/glz095

M3 - Article

C2 - 30977813

AN - SCOPUS:85074965236

SN - 1079-5006

VL - 74

SP - 1959

EP - 1964

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

IS - 12

ER -

Greater Periaortic Fat Volume at Midlife Is Associated with Slower Gait Speed Later in Life in Women: The SWAN Cardiovascular Fat Ancillary Study

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

Publisher link

Find It

Other files and links

Fingerprint

Cite this