Greater efficacy of SPF 100+ sunscreen compared with SPF 50+ in sunburn prevention during 5 consecutive days of sunlight exposure: A randomized, double-blind clinical trial

Indermeet Kohli; Cynthia L. Nicholson; Joshua D. Williams; Alexis B. Lyons; In Seok Seo; Prithwiraj Maitra; Xiaoyan Tian; Evren Atillasoy; Henry W. Lim; Iltefat H. Hamzavi

doi:10.1016/j.jaad.2019.09.018

Greater efficacy of SPF 100+ sunscreen compared with SPF 50+ in sunburn prevention during 5 consecutive days of sunlight exposure: A randomized, double-blind clinical trial

Indermeet Kohli, Cynthia L. Nicholson, Joshua D. Williams, Alexis B. Lyons, In Seok Seo, Prithwiraj Maitra, Xiaoyan Tian, Evren Atillasoy, Henry W. Lim, Iltefat H. Hamzavi

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: Beach vacations are high-risk settings for overexposure to ultraviolet radiation. Objective: To compare the sunburn protective efficacy of SPF 50+ and SPF 100+ sunscreens under actual use at the beach. Methods: A prospective, randomized, double-blind, single-center, split-body/face study of 55 healthy individuals. Each participant applied both sunscreens to randomized sides of the face/body for up to 5 consecutive days. Blinded clinical evaluation of erythema by a single grader and objective instrumental assessments, colorimetry, and diffuse reflectance spectroscopy were performed the morning after each sun exposure. Results: After 5 days, 31 (56%) participants had more sunburn on the SPF 50+ side compared to 4 (7%) on the SPF 100+ side. Overall, mean erythema intensity showed statistically significantly less erythema on the SPF 100+ side compared with the SPF 50+ side. The first observation of sunburn exclusively on the SPF 50+ side occurred after 1 day of sun exposure, whereas that for SPF 100+ occurred after 3 days of sun exposure. Limitations: Only initial sunscreen application was monitored, only 1 participant with skin phototype I was recruited, and participants were recruited from a local beach area. Conclusion: SPF 100+ was significantly more effective in protecting against ultraviolet radiation–induced erythema and sunburn than SPF 50+ in actual use in a beach vacation setting.

Original language	English (US)
Pages (from-to)	869-877
Number of pages	9
Journal	Journal of the American Academy of Dermatology
Volume	82
Issue number	4
DOIs	https://doi.org/10.1016/j.jaad.2019.09.018
State	Published - Apr 2020
Externally published	Yes

Bibliographical note

Funding Information:
Supported by Johnson & Johnson Consumer Inc. The funding source was involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Funding Information:
Supported by Johnson & Johnson Consumer Inc. The funding source was involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.

Publisher Copyright:
© 2020

Keywords

SPF
beach
clinical research
general dermatology
medical dermatology
prevention
sun protection factor
sunlight
sunscreen
vacation

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10.1016/j.jaad.2019.09.018

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Kohli, I., Nicholson, C. L., Williams, J. D., Lyons, A. B., Seo, I. S., Maitra, P., Tian, X., Atillasoy, E., Lim, H. W., & Hamzavi, I. H. (2020). Greater efficacy of SPF 100+ sunscreen compared with SPF 50+ in sunburn prevention during 5 consecutive days of sunlight exposure: A randomized, double-blind clinical trial. Journal of the American Academy of Dermatology, 82(4), 869-877. https://doi.org/10.1016/j.jaad.2019.09.018

Greater efficacy of SPF 100+ sunscreen compared with SPF 50+ in sunburn prevention during 5 consecutive days of sunlight exposure: A randomized, double-blind clinical trial. / Kohli, Indermeet; Nicholson, Cynthia L.; Williams, Joshua D. et al.
In: Journal of the American Academy of Dermatology, Vol. 82, No. 4, 04.2020, p. 869-877.

Research output: Contribution to journal › Article › peer-review

Kohli, I, Nicholson, CL, Williams, JD, Lyons, AB, Seo, IS, Maitra, P, Tian, X, Atillasoy, E, Lim, HW & Hamzavi, IH 2020, 'Greater efficacy of SPF 100+ sunscreen compared with SPF 50+ in sunburn prevention during 5 consecutive days of sunlight exposure: A randomized, double-blind clinical trial', Journal of the American Academy of Dermatology, vol. 82, no. 4, pp. 869-877. https://doi.org/10.1016/j.jaad.2019.09.018

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title = "Greater efficacy of SPF 100+ sunscreen compared with SPF 50+ in sunburn prevention during 5 consecutive days of sunlight exposure: A randomized, double-blind clinical trial",

abstract = "Background: Beach vacations are high-risk settings for overexposure to ultraviolet radiation. Objective: To compare the sunburn protective efficacy of SPF 50+ and SPF 100+ sunscreens under actual use at the beach. Methods: A prospective, randomized, double-blind, single-center, split-body/face study of 55 healthy individuals. Each participant applied both sunscreens to randomized sides of the face/body for up to 5 consecutive days. Blinded clinical evaluation of erythema by a single grader and objective instrumental assessments, colorimetry, and diffuse reflectance spectroscopy were performed the morning after each sun exposure. Results: After 5 days, 31 (56%) participants had more sunburn on the SPF 50+ side compared to 4 (7%) on the SPF 100+ side. Overall, mean erythema intensity showed statistically significantly less erythema on the SPF 100+ side compared with the SPF 50+ side. The first observation of sunburn exclusively on the SPF 50+ side occurred after 1 day of sun exposure, whereas that for SPF 100+ occurred after 3 days of sun exposure. Limitations: Only initial sunscreen application was monitored, only 1 participant with skin phototype I was recruited, and participants were recruited from a local beach area. Conclusion: SPF 100+ was significantly more effective in protecting against ultraviolet radiation–induced erythema and sunburn than SPF 50+ in actual use in a beach vacation setting.",

keywords = "SPF, beach, clinical research, general dermatology, medical dermatology, prevention, sun protection factor, sunlight, sunscreen, vacation",

author = "Indermeet Kohli and Nicholson, {Cynthia L.} and Williams, {Joshua D.} and Lyons, {Alexis B.} and Seo, {In Seok} and Prithwiraj Maitra and Xiaoyan Tian and Evren Atillasoy and Lim, {Henry W.} and Hamzavi, {Iltefat H.}",

note = "Funding Information: Supported by Johnson & Johnson Consumer Inc. The funding source was involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Funding Information: Supported by Johnson & Johnson Consumer Inc. The funding source was involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: {\textcopyright} 2020",

year = "2020",

month = apr,

doi = "10.1016/j.jaad.2019.09.018",

language = "English (US)",

volume = "82",

pages = "869--877",

journal = "Journal of the American Academy of Dermatology",

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T1 - Greater efficacy of SPF 100+ sunscreen compared with SPF 50+ in sunburn prevention during 5 consecutive days of sunlight exposure

T2 - A randomized, double-blind clinical trial

AU - Kohli, Indermeet

AU - Nicholson, Cynthia L.

AU - Williams, Joshua D.

AU - Lyons, Alexis B.

AU - Seo, In Seok

AU - Maitra, Prithwiraj

AU - Tian, Xiaoyan

AU - Atillasoy, Evren

AU - Lim, Henry W.

AU - Hamzavi, Iltefat H.

N1 - Funding Information: Supported by Johnson & Johnson Consumer Inc. The funding source was involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Funding Information: Supported by Johnson & Johnson Consumer Inc. The funding source was involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication. Publisher Copyright: © 2020

PY - 2020/4

Y1 - 2020/4

N2 - Background: Beach vacations are high-risk settings for overexposure to ultraviolet radiation. Objective: To compare the sunburn protective efficacy of SPF 50+ and SPF 100+ sunscreens under actual use at the beach. Methods: A prospective, randomized, double-blind, single-center, split-body/face study of 55 healthy individuals. Each participant applied both sunscreens to randomized sides of the face/body for up to 5 consecutive days. Blinded clinical evaluation of erythema by a single grader and objective instrumental assessments, colorimetry, and diffuse reflectance spectroscopy were performed the morning after each sun exposure. Results: After 5 days, 31 (56%) participants had more sunburn on the SPF 50+ side compared to 4 (7%) on the SPF 100+ side. Overall, mean erythema intensity showed statistically significantly less erythema on the SPF 100+ side compared with the SPF 50+ side. The first observation of sunburn exclusively on the SPF 50+ side occurred after 1 day of sun exposure, whereas that for SPF 100+ occurred after 3 days of sun exposure. Limitations: Only initial sunscreen application was monitored, only 1 participant with skin phototype I was recruited, and participants were recruited from a local beach area. Conclusion: SPF 100+ was significantly more effective in protecting against ultraviolet radiation–induced erythema and sunburn than SPF 50+ in actual use in a beach vacation setting.

AB - Background: Beach vacations are high-risk settings for overexposure to ultraviolet radiation. Objective: To compare the sunburn protective efficacy of SPF 50+ and SPF 100+ sunscreens under actual use at the beach. Methods: A prospective, randomized, double-blind, single-center, split-body/face study of 55 healthy individuals. Each participant applied both sunscreens to randomized sides of the face/body for up to 5 consecutive days. Blinded clinical evaluation of erythema by a single grader and objective instrumental assessments, colorimetry, and diffuse reflectance spectroscopy were performed the morning after each sun exposure. Results: After 5 days, 31 (56%) participants had more sunburn on the SPF 50+ side compared to 4 (7%) on the SPF 100+ side. Overall, mean erythema intensity showed statistically significantly less erythema on the SPF 100+ side compared with the SPF 50+ side. The first observation of sunburn exclusively on the SPF 50+ side occurred after 1 day of sun exposure, whereas that for SPF 100+ occurred after 3 days of sun exposure. Limitations: Only initial sunscreen application was monitored, only 1 participant with skin phototype I was recruited, and participants were recruited from a local beach area. Conclusion: SPF 100+ was significantly more effective in protecting against ultraviolet radiation–induced erythema and sunburn than SPF 50+ in actual use in a beach vacation setting.

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KW - beach

KW - clinical research

KW - general dermatology

KW - medical dermatology

KW - prevention

KW - sun protection factor

KW - sunlight

KW - sunscreen

KW - vacation

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Greater efficacy of SPF 100+ sunscreen compared with SPF 50+ in sunburn prevention during 5 consecutive days of sunlight exposure: A randomized, double-blind clinical trial

Abstract

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Keywords

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