Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131

James R Johnson; Stephen B. Porter; Paul Thuras; Tim Johnson; Lance B. Price; Veronika Tchesnokova; Evgeni V. Sokurenko

doi:10.1128/AAC.01687-15

Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131

James R Johnson, Stephen B. Porter, Paul Thuras, Tim Johnson, Lance B. Price, Veronika Tchesnokova, Evgeni V. Sokurenko

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Abstract

Minimum bactericidal concentrations (MBCs) for ciprofloxacin were significantly higher among 41 members of the H30 subclone within Escherichia coli sequence type 131 than among 48 other fluoroquinolone-resistant E. coli isolates. This MBC difference, which was not explained by ciprofloxacin MICs, gyrA, parC, and parE mutations, the presence of aac(6=)-Ib-cr, or organic solvent tolerance (a surrogate for efflux pump activity), conceivably could have promoted the pandemic emergence of the H30 sequence type 131 subclone.

Original language	English (US)
Pages (from-to)	7132-7135
Number of pages	4
Journal	Antimicrobial agents and chemotherapy
Volume	59
Issue number	11
DOIs	https://doi.org/10.1128/AAC.01687-15
State	Published - Nov 1 2015

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Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Copyright 2018 Elsevier B.V., All rights reserved.

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Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131. / Johnson, James R; Porter, Stephen B.; Thuras, Paul et al.
In: Antimicrobial agents and chemotherapy, Vol. 59, No. 11, 01.11.2015, p. 7132-7135.

Research output: Contribution to journal › Article › peer-review

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Greater ciprofloxacin tolerance as a possible selectable phenotype underlying the pandemic spread of the H30 subclone of Escherichia coli sequence type 131

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