Graves' Ophthalmopathy: A review of immunogenetics

Omid Khalilzadeh, Sina Noshad, Armin Rashidi, Aliakbar Amirzargar

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

Graves' disease (GD) is the most common cause of thyrotoxicosis and often involves the orbits. Graves' ophthalmopathy (GO), also known as Thyroid Eye Disease (TED), can be clinically significant and advance to sightthreatening stages. Our knowledge of the immunogenetic pathophysiology of GO is rapidly expanding. The present review is an attempt to summarize the current state of knowledge on the immunogenetics of GO. First we briefly review the epidemiology and clinical importance of GO, and then we describe in detail the macromolecular pathogenesis and finally immunogenetics of GO. Discrepancies between the results from various reports and the limitations of the available data are discussed. In particular, there is a scarcity of data from non-Asian populations. While several studies have demonstrated significant associations between polymorphisms in certain genes (especially CTLA-4, HLA-DRB-1, and TNF-α), there is a need for studies that investigate the relationship between polymorphisms and both serum and local concentrations of the resulting proteins. A complete understanding of GO susceptibility and pathogenesis has not been yet possible due to a number of important knowledge gaps that need to be filled by future research.

Original languageEnglish (US)
Pages (from-to)564-575
Number of pages12
JournalCurrent Genomics
Volume12
Issue number8
DOIs
StatePublished - Dec 2011

Keywords

  • Cytokine
  • Graves
  • Immunogenetics
  • Ophthalmopathy
  • Polymorphism

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