Using assistant reagents to improve the pharmaceutical performance of cisplatin (CDDP) has been one of promising strategies. Owing to their extraordinary properties, graphene quantum dots (GQDs) have shown great potentials in biomedical applications. Here we demonstrate that the combination of GQDs with CDDP can effectively enhance the cytotoxicity, cell cycle arrest, and DNA fragmentation that induced by CDDP. We also found that the GQDs improved the interaction of CDDP with DNA. Combing these results with our previous finding that graphene oxide could enhance the permeability of the cells, we believe GQDs improve the pharmaceutical performance of CDDP via first increasing its cellular uptake through improving the cell permeability, and then reinforcing its interaction with DNA once it is inside cells. The remarkable enhancement to CDDP cellular uptake in CDDP resistant cells further specifies that GQDs can increase chemotherapy efficacy of anticancer drugs that are suboptimal due to the drug resistance.
|Original language||English (US)|
|Number of pages||10|
|Journal||Nanomedicine: Nanotechnology, Biology, and Medicine|
|State||Published - Oct 1 2016|
Bibliographical noteFunding Information:
This research was carried out with financial support from the national “973 Program” of China (Nos. 2015CB931801, 2014CB260411), National Science foundation of China (No. 11374205), the state key laboratory of bioreactor engineering (No. 2060204), 111 Project (No. B07023), the Shanghai Committee of Science and Technology (Nos. 11DZ2260600), and national “863” Program of China (No. 2012AA022603) for financial support of this work..
© 2016 Elsevier Inc.
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- Anticancer activity
- Cell permeability
- Cellular uptake
- Graphene quantum dots