Graphene-edge dielectrophoretic tweezers for trapping of biomolecules

Avijit Barik, Yao Zhang, Roberto Grassi, Binoy Paulose Nadappuram, Joshua B. Edel, Tony Low, Steven J. Koester, Sang Hyun Oh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The many unique properties of graphene, such as the tunable optical, electrical, and plasmonic response make it ideally suited for applications such as biosensing. As with other surface-based biosensors, however, the performance is limited by the diffusive transport of target molecules to the surface. Here we show that atomically sharp edges of monolayer graphene can generate singular electrical field gradients for trapping biomolecules via dielectrophoresis. Graphene-edge dielectrophoresis pushes the physical limit of gradient-force-based trapping by creating atomically sharp tweezers. We have fabricated locally backgated devices with an 8-nm-thick HfO2 dielectric layer and chemical-vapor-deposited graphene to generate 10× higher gradient forces as compared to metal electrodes. We further demonstrate near-100% position-controlled particle trapping at voltages as low as 0.45 V with nanodiamonds, nanobeads, and DNA from bulk solution within seconds. This trapping scheme can be seamlessly integrated with sensors utilizing graphene as well as other two-dimensional materials.

Original languageEnglish (US)
Article number1867
JournalNature communications
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2017

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Graphite
Biomolecules
graphene
trapping
Electrophoresis
gradients
Nanodiamonds
Biosensing Techniques
bioinstrumentation
Biosensors
Monolayers
Electrodes
deoxyribonucleic acid
Metals
Vapors
vapors
Equipment and Supplies
Molecules
electrodes
DNA

How much support was provided by MRSEC?

  • Shared

Reporting period for MRSEC

  • Period 4

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

Cite this

Graphene-edge dielectrophoretic tweezers for trapping of biomolecules. / Barik, Avijit; Zhang, Yao; Grassi, Roberto; Nadappuram, Binoy Paulose; Edel, Joshua B.; Low, Tony; Koester, Steven J.; Oh, Sang Hyun.

In: Nature communications, Vol. 8, No. 1, 1867, 01.12.2017.

Research output: Contribution to journalArticle

Barik, Avijit ; Zhang, Yao ; Grassi, Roberto ; Nadappuram, Binoy Paulose ; Edel, Joshua B. ; Low, Tony ; Koester, Steven J. ; Oh, Sang Hyun. / Graphene-edge dielectrophoretic tweezers for trapping of biomolecules. In: Nature communications. 2017 ; Vol. 8, No. 1.
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