Grapevine stilbenoids: Bioavailability and neuroprotection

Pierre Waffo-Téguo, Stéphanie Krisa, Alison D. Pawlus, Tristan Richard, Jean Pierre Monti, Jean Michel Mérillon

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations


Vine and wine are an abundant source of stilbenoids that constitute a large class of compounds, including a series of monomers and oligomers (dimers, trimers, tetramers). Stilbenoids can reach a level of over 100 mg L − 1 in red wine. Several epidemiological studies have correlated the consumption of grapes and wines with significant health benefits. The most studied stilbenoid, resveratrol, exhibits multiple biological activities across multiple diseases including cancer and cardiovascular and neurodegenerative diseases. This compound shows promise in both the prevention and the treatment of these diseases. Moreover, resveratrol mimics calorie restriction and extends the lifespan in species ranging from yeast to multicellular animals (not in normal mammals) by a sirtuin-dependent mechanism. Resveratrol is well absorbed yet rapidly metabolized; however, the tissue concentrations found in some studies in animals and humans are compatible with its biological activities. Resveratrol is well tolerated at doses of up to 1 g day − 1 in human and does not cause serious adverse events up to 5 g day − 1. Interestingly, other wine and grape stilbenoids such as piceatannol, pterostilbene, viniferins, and vitisins also have beneficial activities. In this chapter, we have discussed chemistry and protective role of stilbenoids in general, and resveratrol in particular, during various pathological conditions such as neurodegeneration, neuroinflammation, cancer, cardiovascular diseases, and antiaging process. Works related to bioavailability and clinical trials of resveratrol are also presented.

Original languageEnglish (US)
Title of host publicationNatural Products
Subtitle of host publicationPhytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes
PublisherSpringer Berlin Heidelberg
Number of pages35
ISBN (Electronic)9783642221446
ISBN (Print)9783642221439
StatePublished - Jan 1 2013

Bibliographical note

Publisher Copyright:
© Springer-Verlag Berlin Heidelberg 2013.


  • Biological activities
  • Polyphenols
  • Resveratrol
  • Toxicity
  • Vitis vinifera


Dive into the research topics of 'Grapevine stilbenoids: Bioavailability and neuroprotection'. Together they form a unique fingerprint.

Cite this