Granulocytic Sarcoma of the Orbit Presenting as a Fulminant Orbitopathy in an Adult with Acute Myeloid Leukemia

John P. O'Neill, Andrew R. Harrison, J. Douglas Cameron, Ali Mokhtarzadeh

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


A 64-year-old woman with relapsed acute myelogenous leukemia (AML) undergoing salvage chemotherapy developed rapid onset of right-sided ophthalmoplegia, proptosis, optic neuropathy, and vision loss from 20/30 to hand motions over a 3-hour period on day 4 of her treatment. CT scan of her orbits revealed a superolateral orbital mass and periocular edema. She underwent immediate canthotomy and cantholysis, and lateral orbitotomy with debulking of the mass later the same day. The histopathology was consistent with aggregates of myeloid blasts. Her vision recovered to 20/20 on postoperative day 1. Orbital granulocytic sarcoma is a rare condition often concurrent with AML, typically in the pediatric population and rarely in adults. Presentation as a fulminant orbitopathy with rapidly progressive optic neuropathy and vision loss over several hours has not been previously reported.

Original languageEnglish (US)
Pages (from-to)S118-S120
JournalOphthalmic plastic and reconstructive surgery
Issue number3S
StatePublished - May 1 2017

Bibliographical note

Funding Information:
This study was supported by an unrestricted grant from the Research to Prevent Blindness (New York, NY), and the Lions and Lionesses of Minnesota.

Publisher Copyright:
© 2016 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.


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