Granulocyte antigen systems and antibodies and their clinical significance

Jeffrey McCullough

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Granulocyte alloantibodies and autoantibodies have a key role in the pathophysiology of several clinical problems. These include febrile transfusion reactions, severe pulmonary reactions to transfusion, isoimmune neonatal neutropenia, failure of effective granulocyte transfusion, autoimmune neutropenia, drug-induced neutropenia, and neutropenias secondary to many other diseases. Although many techniques are available for detecting granulocyte antibodies, the optimal in-vitro tests for predicting the antibodies' clinical effects are not established. Use of indium-111-labeled granulocytes may provide valuable information regarding the in-vivo effects of different granulocyte antibodies. Granulocyte transfusions continue to be used for a limited number of severely infected neutropenic patients who do not respond to antibiotic therapy.

Original languageEnglish (US)
Pages (from-to)228-234
Number of pages7
JournalHuman pathology
Issue number3
StatePublished - Mar 1983

Bibliographical note

Funding Information:
* Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, and American Red Cross Blood Services, St. Paul Region, St. Paul, Minnesota. Supported in part by grant R01 HL26568-03 from the National Heart, Lung and Blood Institute and research flmds from the American Red Cross. Address correspondence and reprint requests to Dr. McCul-Iough: University Hospitals Blood Bank, Box 198, Mayo Memorial Bldg, 420 Delaware St SE, Minneapolis, MN 55455.


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