An improved method for the synthesis of a new quinolone class of antibiotics, which are exceptionally potent against gram-positive bacteria, has been developed and the structure confirmed by single-crystal X-ray analysis. In the course of synthesis, using either Chan-Lam coupling or Buchwald-Hartwig amination, we have shown that the careful choice of protecting group at the C4 position of the quinoline is required for selective amination at the C5 position and subsequent deprotection to avoid the formation of a novel pyrido[4,3,2-de]quinazoline tetracycle.
|Original language||English (US)|
|Journal||Journal of Organic Chemistry|
|State||Accepted/In press - 2023|
Bibliographical noteFunding Information:
This work was supported by RO1 AI146116 and R21 AI130540. We would like to thank Dr. Victor G. Young, Jr. from the Department of Chemistry, University of Minnesota for X-ray crystallographic analysis.
© 2023 American Chemical Society
PubMed: MeSH publication types
- Journal Article