Good-enough brain model: Challenges, algorithms and discoveries in multi-subject experiments

Evangelos E. Papalexakis, Alona Fyshe, Nicholas D. Sidiropoulos, Partha Pratim Talukdar, Tom M. Mitchell, Christos Faloutsos

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

Given a simple noun such as apple, and a question such as "is it edible?", what processes take place in the human brain? More specifically, given the stimulus, what are the interactions between (groups of) neurons (also known as functional connectivity) and how can we automatically infer those interactions, given measurements of the brain activity? Furthermore, how does this connectivity differ across different human subjects? In this work we present a simple, novel good-enough brain model, or GeBM in short, and a novel algorithm Sparse-SysId, which are able to effectively model the dynamics of the neuron interactions and infer the functional connectivity. Moreover, GeBM is able to simulate basic psychological phenomena such as habituation and priming (whose definition we provide in the main text). We evaluate GeBM by using both synthetic and real brain data. Using the real data, GeBM produces brain activity patterns that are strikingly similar to the real ones, and the inferred functional connectivity is able to provide neuroscientific insights towards a better understanding of the way that neurons interact with each other, as well as detect regularities and outliers in multi-subject brain activity measurements.

Original languageEnglish (US)
Title of host publicationKDD 2014 - Proceedings of the 20th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining
PublisherAssociation for Computing Machinery
Pages95-104
Number of pages10
ISBN (Print)9781450329569
DOIs
StatePublished - 2014
Event20th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, KDD 2014 - New York, NY, United States
Duration: Aug 24 2014Aug 27 2014

Publication series

NameProceedings of the ACM SIGKDD International Conference on Knowledge Discovery and Data Mining

Other

Other20th ACM SIGKDD International Conference on Knowledge Discovery and Data Mining, KDD 2014
CountryUnited States
CityNew York, NY
Period8/24/148/27/14

Keywords

  • brain activity analysis
  • brain functional connectivity
  • control theory
  • neuroscience
  • system identification

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