Gonadal dysgenesis and gynecologic cancer

Amy L. Jonson, Melissa A. Geller, Elizabeth L. Dickson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Gonadal dysgenesis encompasses a variety of sexual differentiation disorders. Within this population of patients, there is an increased risk of gonadal tumor formation. Cases: In this case series of three patients, two with Swyer's syndrome (complete gonadal dysgenesis) and one with mosaic Turner's syndrome, three separate histologic subtypes of tumors were identified: dysgerminoma, seminoma, and gonadoblastoma. The patients with dysgerminoma and seminoma had regular menses and were without recurrent disease. We recommend that the patient with gonadoblastoma start on hormone therapy. Conclusion: Once the diagnosis of gonadal dysgenesis is made, prophylactic gonadectomy should be performed owing to the probability of malignant transformation. These patients illustrate the potential different presentations with gonadal dysgenesis and the importance of complete evaluation of patients with primary amenorrhea.

Original languageEnglish (US)
Pages (from-to)550-552
Number of pages3
JournalObstetrics and gynecology
Volume116
Issue number2 PART 2
DOIs
StatePublished - Aug 1 2010

Fingerprint

Gonadal Dysgenesis
Gonadoblastoma
Dysgerminoma
Neoplasms
Seminoma
46,XY Gonadal Dysgenesis
Disorders of Sex Development
Turner Syndrome
Menstruation
Amenorrhea
Hormones
Population

Cite this

Gonadal dysgenesis and gynecologic cancer. / Jonson, Amy L.; Geller, Melissa A.; Dickson, Elizabeth L.

In: Obstetrics and gynecology, Vol. 116, No. 2 PART 2, 01.08.2010, p. 550-552.

Research output: Contribution to journalArticle

Jonson, Amy L. ; Geller, Melissa A. ; Dickson, Elizabeth L. / Gonadal dysgenesis and gynecologic cancer. In: Obstetrics and gynecology. 2010 ; Vol. 116, No. 2 PART 2. pp. 550-552.
@article{45f12183463e418aada000eba8241e57,
title = "Gonadal dysgenesis and gynecologic cancer",
abstract = "Background: Gonadal dysgenesis encompasses a variety of sexual differentiation disorders. Within this population of patients, there is an increased risk of gonadal tumor formation. Cases: In this case series of three patients, two with Swyer's syndrome (complete gonadal dysgenesis) and one with mosaic Turner's syndrome, three separate histologic subtypes of tumors were identified: dysgerminoma, seminoma, and gonadoblastoma. The patients with dysgerminoma and seminoma had regular menses and were without recurrent disease. We recommend that the patient with gonadoblastoma start on hormone therapy. Conclusion: Once the diagnosis of gonadal dysgenesis is made, prophylactic gonadectomy should be performed owing to the probability of malignant transformation. These patients illustrate the potential different presentations with gonadal dysgenesis and the importance of complete evaluation of patients with primary amenorrhea.",
author = "Jonson, {Amy L.} and Geller, {Melissa A.} and Dickson, {Elizabeth L.}",
year = "2010",
month = "8",
day = "1",
doi = "10.1097/AOG.0b013e3181e4bfe9",
language = "English (US)",
volume = "116",
pages = "550--552",
journal = "Obstetrics and Gynecology",
issn = "0029-7844",
publisher = "Lippincott Williams and Wilkins",
number = "2 PART 2",

}

TY - JOUR

T1 - Gonadal dysgenesis and gynecologic cancer

AU - Jonson, Amy L.

AU - Geller, Melissa A.

AU - Dickson, Elizabeth L.

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: Gonadal dysgenesis encompasses a variety of sexual differentiation disorders. Within this population of patients, there is an increased risk of gonadal tumor formation. Cases: In this case series of three patients, two with Swyer's syndrome (complete gonadal dysgenesis) and one with mosaic Turner's syndrome, three separate histologic subtypes of tumors were identified: dysgerminoma, seminoma, and gonadoblastoma. The patients with dysgerminoma and seminoma had regular menses and were without recurrent disease. We recommend that the patient with gonadoblastoma start on hormone therapy. Conclusion: Once the diagnosis of gonadal dysgenesis is made, prophylactic gonadectomy should be performed owing to the probability of malignant transformation. These patients illustrate the potential different presentations with gonadal dysgenesis and the importance of complete evaluation of patients with primary amenorrhea.

AB - Background: Gonadal dysgenesis encompasses a variety of sexual differentiation disorders. Within this population of patients, there is an increased risk of gonadal tumor formation. Cases: In this case series of three patients, two with Swyer's syndrome (complete gonadal dysgenesis) and one with mosaic Turner's syndrome, three separate histologic subtypes of tumors were identified: dysgerminoma, seminoma, and gonadoblastoma. The patients with dysgerminoma and seminoma had regular menses and were without recurrent disease. We recommend that the patient with gonadoblastoma start on hormone therapy. Conclusion: Once the diagnosis of gonadal dysgenesis is made, prophylactic gonadectomy should be performed owing to the probability of malignant transformation. These patients illustrate the potential different presentations with gonadal dysgenesis and the importance of complete evaluation of patients with primary amenorrhea.

UR - http://www.scopus.com/inward/record.url?scp=77955155871&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955155871&partnerID=8YFLogxK

U2 - 10.1097/AOG.0b013e3181e4bfe9

DO - 10.1097/AOG.0b013e3181e4bfe9

M3 - Article

C2 - 20664451

AN - SCOPUS:77955155871

VL - 116

SP - 550

EP - 552

JO - Obstetrics and Gynecology

JF - Obstetrics and Gynecology

SN - 0029-7844

IS - 2 PART 2

ER -