Gold nanoparticle decoration of DNA on silicon

Gary Braun, Katsuhiko Inagaki, R. August Estabrook, D. K. Wood, Eran Levy, A. N. Cleland, Geoffrey F. Strouse, Norbert O. Reich

Research output: Contribution to journalArticle

39 Scopus citations


Electrostatic assembly of cationic nanoparticles onto the negatively charged backbone of double-stranded DNA has been shown to produce one-dimensional chains with potential use as nanoelectronic components. In this paper, micron long DNA templates stretched on aminosilane- and hexamethyldisilazane-modified silicon surfaces are used to assemble 3.5 nm gold nanoparticles passivated with cationic thiocholine. Atomic force microscopy is used to analyze the density and defects along the ∼5 nm high structures, with comparison between positively charged and neutral surfaces. Low background adsorption of nanoparticles is facilitated by both these surface chemistries, while the neutral surface yields a more densely packed assembly.

Original languageEnglish (US)
Pages (from-to)10699-10701
Number of pages3
Issue number23
StatePublished - Nov 8 2005

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    Braun, G., Inagaki, K., Estabrook, R. A., Wood, D. K., Levy, E., Cleland, A. N., Strouse, G. F., & Reich, N. O. (2005). Gold nanoparticle decoration of DNA on silicon. Langmuir, 21(23), 10699-10701.