Goitrous hypothyroidism associated with treatment with trimethoprim- sulfamethoxazole in a young dog

Davis M. Seelig, Jacqueline C. Whittemore, Michael R. Lappin, Alan M. Myers, Paul R. Avery

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Case Description - A 16-week-old female Boxer that had been treated for 5 weeks with trimethoprim-sulfamethoxazole and chloramphenicol because of aspiration pneumonia was evaluated for bilaterally symmetric masses in the subcutaneous tissues of the ventral neck, in the region of the larynx. Clinical Findings - Fine-needle aspirates were obtained from the neck masses; cytologic examination revealed well-differentiated thyroid epithelial tissue. A blood sample was collected for serum biochemical and thyroid function analyses. Mild hyperphosphatemia, severe hypercholesterolemia, mild hyperkalemia, and a mild increase in creatine kinase activity were identified. Serum concentration of total thyroxine was less than the lower reference limit, and that of thyroid-stimulating hormone was greater than the upper reference limit. Findings were consistent with a diagnosis of clinical hypothyroidism in a skeletally immature dog. Treatment and Outcome - Treatment with trimethoprim- sulfamethoxazole was discontinued. The dog was reevaluated 3 weeks later, at which time the neck masses were markedly decreased in size. Serum concentrations of cholesterol and potassium were lower; serum concentrations of total thyroxine and thyroid-stimulating hormone were near or within respective reference ranges. Age-appropriate increases in serum phosphorus concentration and serum alkaline phosphatase activity were also detected. Clinical Relevance - To the authors' knowledge, this is the first report of antimicrobialinduced goiter in a dog. Cytologic examination of fine-needle aspirates and interpretation of data from serum biochemical and thyroid function analyses were needed to obtain a definitive diagnosis. Practitioners should include goiter among the differential diagnoses for ventral neck swellings in young dogs receiving potentiated sulfonamide antimicrobials.

Original languageEnglish (US)
Pages (from-to)1181-1185
Number of pages5
JournalJournal of the American Veterinary Medical Association
Volume232
Issue number8
DOIs
StatePublished - Apr 15 2008

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sulfamethoxazole
hypothyroidism
trimethoprim
Sulfamethoxazole Drug Combination Trimethoprim
Hypothyroidism
blood serum
Dogs
dogs
neck
Serum
Neck
goiter
thyroid function
Thyroid Gland
thyrotropin
Goiter
Thyrotropin
thyroxine
Thyroxine
Needles

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Goitrous hypothyroidism associated with treatment with trimethoprim- sulfamethoxazole in a young dog. / Seelig, Davis M.; Whittemore, Jacqueline C.; Lappin, Michael R.; Myers, Alan M.; Avery, Paul R.

In: Journal of the American Veterinary Medical Association, Vol. 232, No. 8, 15.04.2008, p. 1181-1185.

Research output: Contribution to journalArticle

Seelig, Davis M. ; Whittemore, Jacqueline C. ; Lappin, Michael R. ; Myers, Alan M. ; Avery, Paul R. / Goitrous hypothyroidism associated with treatment with trimethoprim- sulfamethoxazole in a young dog. In: Journal of the American Veterinary Medical Association. 2008 ; Vol. 232, No. 8. pp. 1181-1185.
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