Abstract
A study of a series of S-alkylglutathiones as inhibitors of the enzyme, glyoxalase I, revealed that a non-polar region exists on the enzyme which plays an important role in the formation of an enzyme-inhibitor complex. The amount of inhibition of glyoxalase increases as the alkyl chain is lengthened from methyl to n-octyl. By taking advantage of the non-polar region of the enzyme, compounds have been prepared which are 435 times more active than the previously reported S-methylglutathione.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 593-598 |
| Number of pages | 6 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jun 6 1969 |
Bibliographical note
Funding Information:*Supported by Grant CA-10979-01 from the National Cancer Institute from the Minnesota Division of the American Cancer Society.
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SDG 3 Good Health and Well-being
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