Glyoxalase Inhibitors. A Possible Approach to Anticancer Agents

Robert Vince; Susan Daluge

doi:10.1021/jm00283a009

Glyoxalase Inhibitors. A Possible Approach to Anticancer Agents

Robert Vince
, Susan Daluge

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

Some glyoxalase I enzyme inhibitors were assayed for cytotoxic activity against L1210 leukemia and KB cells in tissue culture. Sublethal concentrations of glyoxalase inhibitor caused a 14- to 18-fold increase in methylglyoxal toxicity in L1210 cells. A probable mechanism for the cytotoxic activity of methylglyoxal is discussed.

Original language	English (US)
Pages (from-to)	35-37
Number of pages	3
Journal	Journal of medicinal chemistry
Volume	14
Issue number	1
DOIs	https://doi.org/10.1021/jm00283a009
State	Published - Jan 1 1971

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title = "Glyoxalase Inhibitors. A Possible Approach to Anticancer Agents",

abstract = "Some glyoxalase I enzyme inhibitors were assayed for cytotoxic activity against L1210 leukemia and KB cells in tissue culture. Sublethal concentrations of glyoxalase inhibitor caused a 14- to 18-fold increase in methylglyoxal toxicity in L1210 cells. A probable mechanism for the cytotoxic activity of methylglyoxal is discussed.",

author = "Robert Vince and Susan Daluge",

year = "1971",

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doi = "10.1021/jm00283a009",

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T1 - Glyoxalase Inhibitors. A Possible Approach to Anticancer Agents

AU - Vince, Robert

AU - Daluge, Susan

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AB - Some glyoxalase I enzyme inhibitors were assayed for cytotoxic activity against L1210 leukemia and KB cells in tissue culture. Sublethal concentrations of glyoxalase inhibitor caused a 14- to 18-fold increase in methylglyoxal toxicity in L1210 cells. A probable mechanism for the cytotoxic activity of methylglyoxal is discussed.

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UR - https://www.scopus.com/pages/publications/0014974643#tab=citedBy

U2 - 10.1021/jm00283a009

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JO - Journal of medicinal chemistry

JF - Journal of medicinal chemistry

IS - 1

ER -

Glyoxalase Inhibitors. A Possible Approach to Anticancer Agents

Abstract

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